The level of cardiac output affects the relationship and agreement between pulmonary artery and transpulmonary aortic thermodilution measurements in an animal model.

Objective: The authors investigated the relationship between pulmonary artery and transpulmonary aortic thermodilution cardiac output measurements under conditions of increasing cardiac output (CO).

Design: Animal study with repeated simultaneous measurements comparing 2 cardiac output measurement techniques.

Setting: Experimental animal facility of a university hospital.

The effects of urapidil on thermoregulatory thresholds in volunteers.

Unlabelled: In a previous study we have shown that the antihypertensive drug, urapidil, stops postanesthetic shivering. One possible mechanism in the inhibition of postanesthetic shivering by urapidil may be alterations in thermoregulatory thresholds. We therefore studied the effects of urapidil on vasoconstriction and shivering thresholds during cold-induced shivering in volunteers.