Single-Procedure Outcomes and Quality-of-Life Improvement 12 Months Post-Cryoballoon Ablation in Persistent Atrial Fibrillation: Results From the Multicenter CRYO4PERSISTENT AF Trial.

Objectives: The CRYO4PERSISTENT AF (Cryoballoon Ablation for Early Persistent Atrial Fibrillation) trial aims to report long-term outcomes after a single pulmonary vein isolation (PVI)-only ablation procedure using the second-generation cryoballoon in persistent atrial fibrillation (PerAF) patients.

Background: Pulmonary vein isolation is recognized as the cornerstone of atrial fibrillation (AF) ablation, including ablation of PerAF.

Methods: The CRYO4PERSISTENT AF trial (NCT02213731) is a prospective, multicenter, single-arm trial designed to assess single-procedure outcomes of PVI using the cryoballoon.

[Fragments of medico-historical interest in the Landeskirchliche Archiv Kassel].

A systematic survey in the Landeskirchliche Archiv Kassel of medieval manuscript fragments which have survived in the binding of documents in parish archives has uncovered a treasure of liturgical, theological and legal texts. This paper presents two fragments of medico-historical interest: two folios from a pharmaceutical treatise, which could not be identified more precisely, and a passage from the commentary to Gilles de Corbeil's well-known 'Carmen de urinis'. A modern edition of this commentary, which was probably written by Gilles himself, would be very welcome.

[Appendix to the "Darmstadt Johannes-Alexandrinus Fragment"].

This appendix to "Das Darmstädter Johannes-Alexandrinus-Fragment" answers to the critical note by Klaus-Dietrich Fischer, and shows that these new-founded fragments are a testimony of an until now unknown abbreviated version of the Alexandrinian commentary on Galen's book 'De sectis'.