Publications by authors named "Konrad Czajkowski"
Senolytics: charting a new course or enhancing existing anti-tumor therapies?
Cell Oncol (Dordr)
December 2024
Article Synopsis
- - Cell senescence starts as a protective mechanism against tumors but can eventually lead to cancer recurrence and damage to surrounding tissues due to the buildup of senescent cells.
- - Senescent cells release bioactive molecules known as the senescence-associated secretory phenotype (SASP), which can cause chronic inflammation and promote tumor growth through signaling to nearby cells.
- - Senolytic drugs target and remove senescent cells, potentially enhancing cancer treatments by preventing tumor recurrence and allowing safer, lower doses of chemotherapy or radiotherapy, making them a promising option in personalized cancer therapy.