Influence of and gene polymorphisms on pharmacokinetics of apixaban in patients with atrial fibrillation and acute stroke.

Introduction: Difficulties in non-vitamin K anticoagulant (NOAC) administration in acute stroke can be associated with changes in pharmacokinetic parameters of NOAC such as biotransformation, distribution, and excretion. Therefore, obtaining data on pharmacokinetics of NOAC and factors that affect it may help develop algorithms for personalized use of this drug class in patients with acute cardioembolic stroke.

Patients And Methods: Pharmacokinetics of apixaban in patients with acute stroke was studied earlier by Kryukov et al.

Genetic Polymorphisms of Cytochrome P450 Enzymes and Transport Proteins in a Russian Population and Three Ethnic Groups of Dagestan.

Aim: The objective of this study was to investigate the prevalence of polymorphic markers of the CYP2C19, CYP2C9, CYP2D6, SLCO1B1, and ABCB1 genes among the three ethnic groups in Dagestan and compare it with the carrier frequency of these markers among the Russian population living in Moscow.

Methods: The study involved 186 healthy, unrelated, and chronic medication-free volunteers (53 males and 133 females) of the three ethnic groups in the Dagestan Republic: 46 Laks, 90 Avars, and 50 Dargins. Genotyping was performed using real-time polymerase chain reaction-based methods.

[The evaluation of the effectiveness of electrophoresis in the form of Polymineral wipes on the basis of iodine- bromine natural water in the young children suffering from the consequences of perinatal lesions in the central nervous system].

Unlabelled: The background: the increased frequency of serious consequences of perinatal lesions in the central nervous system of the young children dictates the necessity to develop the effective methods of physiotherapy for the early-stage rehabilitation of such patients on the basis of an objective assessment of the adaptive reserves of the organism.

Material And Methods: The present study involved 53 children at the age from 1 to 12 months presenting with the consequences of perinatal lesions to the central nervous system. Thirty of the children were treated with the use of electrophoresis in the form of Polymineral wipes on the basis of natural iodine-bromine water.

[The role of enteral oxygen-therapy in the correction of functional disturbances in the autonomic nervous system of the children presenting with chronic diseases of the respiratory organs].

Background: Vegetative dysfunction is observed in 60-90% of the children presenting with chronic respiratory diseases. Its timely identification and correction increases the effectiveness of the combined rehabilitative treatment of such patients.

Material And Methods: The vegetative regulation was dynamically evaluated by the analysis of the heart rate variability in 95 patients presenting with bronchial asthma and chronic nonspecific lung diseases.

[The influence of the pearl baths on the dynamics of cerebral circulation in the children presenting with the consequences of perinatal lesions in the central nervous system].

The present article is concerned with the problem of rehabilitation of the children at the age from 6 to 12 months presenting with perinatal lesions in the central nervous system (CNS) and the role of cerebral hemodynamics in the development of this disease. The results of dynamic clinical and laboratory examination of the children presenting with the consequences of perinatal lesions in the central nervous system are presented with special reference to the influence of the pearl baths on the dynamics of cerebral circulation. The study involving 65 patients showed that the inclusion of bubble bath sin the combined rehabilitative treatment of the children with this condition helps to optimize parameters of the disturbed cerebral blood flow.

[Intravesical electrostimulation and magnetotherapy in chronic pyelonephritis and cystitis in children with urodynamic disorders].

The results of the treatment of 38 children (6 boys and 32 girls, age 6-14 years) with chronic pyelonephritis and/or cystitis complicated with neurogenic dysfunction of the urinary bladder (NDUB) and/or vesicoureteral reflux (VUR) of the first-third degree demonstrate efficacy of intravesical electrostimulation (IVES) and adrenal magnetotherapy. IVES was conducted with high-frequency current impulses (2.2 kHz) by means of INTRASTIM attachment to the device AMUS-01-INTRAMAG in the region of the urethrovesical anastomosis via solution of the drugs for instillation.

[Infitatherapy of children with bronchial asthma].

Use of nonmedicamental methods of treatment assists to improve the control of children's bronchial asthma clinical course. Pulsed low-frequency electromagnetic field regulates the state of central and vegetative nervous system and improves psychological status of child. Inphytotherapy has bronchial spasmolytic and immune correction effects.

[The effect of a low-frequency alternating magnetic field on the autonomic nervous system in children with primary arterial hypertension].

The paper provides cardiointervalographic data assessing autonomic nervous system (ANS) function in children with primary arterial hypertension exposed to low-frequency alternating magnetic field. Favourable effects of such magnetotherapy manifest in attenuation of sympathetic and vagotonic symptoms.

Biosynthesis of extracellular low-molecular-mass papain and trypsin inhibitors by Streptomyces sp. 22: effect of cultural conditions.

The production of extracellular inhibitors of papain and trypsin by Streptomyces sp. 22 was studied under different cultural conditions including complex and defined media, temperatures ranging from 18 degrees C to 37 degrees C and a variety of sole carbon and nitrogen sources. In complex nutritionally rich medium, maximal specific growth rates were obtained at 37 degrees C, whereas the highest specific production rates for both papain and trypsin inhibitors were registered at 18 degrees C.

Screening of microorganisms for enzyme-inhibiting activities.

In the course of a screening for extracellular inhibitors of 8 different proteinases 140 actinomycete and 150 mould strains were examined. 130 fungal and 50 actinomycete strains were similarly tested for the production of extracellular inhibitors of dihydrofolate reductase (DHFR) and alkaline phosphatase (APh). Most of the inhibitors found in the culture media of the actinomycete and mould strains were specific against serine proteinases.