Publications by authors named "Konika Choudhury"
Article Synopsis
- * The study developed doxorubicin-loaded mesoporous silica nanoparticles (DMSNs) from cucumber peels to target lung adenocarcinoma cells, showing effective drug delivery and antibacterial properties against infections common in lung cancer patients.
- * This method not only offers a promising anticancer treatment but also promotes sustainability by turning food waste into useful medical nanoparticles, aligning with the waste-to-health paradigm.
Article Synopsis
- Triple-negative breast cancer (TNBC) is highly aggressive due to a lack of targetable bioreceptors and features like epithelial to mesenchymal transition (EMT), which enhances its metastatic abilities.
- Researchers developed a combination therapy using promethazine hydrochloride-loaded PLGA nanoparticles, which showed efficient delivery and anti-cancer effects in experimental studies, particularly when used alongside the histone deacetylase inhibitor SAHA.
- The study found that SAHA not only increased the effectiveness of the drug-loaded nanoparticles but also altered EMT dynamics, promoting a shift towards less aggressive cancer cell characteristics, thus highlighting the potential of combining nanotechnology with repurposed drugs for treating TNBC.
Drug repurposing presents a workable strategy in tackling antibiotic resistance. Many known drugs have been repurposed for their applications against different targets. Antihistamines that are usually used to treat allergy symptoms can be combined with nanoscale materials to enhance their efficiency.
View Article and Find Full Text PDFMycobacterium tuberculosis (Mtb) secretes proteases and peptidases to subjugate its host. Out of its sixty plus proteases, atleast three are reported to reach host macrophages. In this study, we show that Mtb also delivers a lysyl alanine aminopeptidase, PepN (Rv2467) into host macrophage cytosol.
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