Publications by authors named "Kongyan Wang"
Acute pulmonary inflammation is a severe lower respiratory tract infection. Sinensetin (SIN), a polymethoxyflavone with strong anti-inflammatory properties, is known to ameliorate LPS-induced acute inflammatory lung injury, but its molecular mechanisms are not fully understood. This study aimed to provide insight into the pharmacological mechanisms of SIN in attenuating acute pulmonary inflammation.
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- Sinensetin (SIN), a compound found in citrus fruits, shows strong antioxidant and anti-inflammatory effects that can help reduce lung injuries caused by inflammation.
- In studies using a mouse model of acute lung injury induced by LPS and a cell model for inflammation, SIN was found to lower levels of key inflammatory markers and reduce immune cell infiltration into the lungs.
- RNA sequencing and mechanistic analyses indicated that SIN works by inhibiting a specific inflammatory pathway (NLRP3), preventing severe inflammatory responses and cell death, highlighting its potential for therapeutic use against lung injuries.
Ethnopharmacological Relevance: Exocarpium Citri Grandis (ECG), the epicarp of C. grandis 'Tomentosa' which is also known as Hua-Ju-Hong in China, has been widely used for thousands of years to treat inflammatory lung disorders such as asthma, and cough as well as dispelling phlegm. However, its underlying pharmacological mechanisms in acute lung injury (ALI) remain unclear.
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