Publications by authors named "Kongrui Zhu"
With the wide utilization of organophosphate esters (OPEs) in recent years, OPEs have been detected more frequently in the aquatic environment. However, the distribution of OPEs in drinking source water has rarely been investigated across a large region. In this study, the occurrence and distribution of 13 OPEs were investigated in 23 source water sites from Northeast to Southeast (spacing greater than 3320 km) with a direct injection ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method.
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- The study investigates the effects of aryl-organophosphate flame retardants (OPFRs), TPhP and TDCIPP, on estrogen receptors, challenging the notion that traditional ERα binding assays fully explain their biological impacts.
- TPhP was identified as an ERα agonist that activates steroid receptor co-activators, whereas TDCIPP functions as an ERα antagonist; both compounds can activate the estrogen pathway via GPER in cells lacking ERα.
- The research demonstrates that both TPhP and TDCIPP enhance the synthesis of 17β-estradiol (E2) through different mechanisms, affecting the levels of other hormones and gene expression, thereby proposing frameworks for understanding their estrogen-disrupt
Phosphorus-containing flame retardants (PFRs) have been frequently detected in various environmental samples at relatively high concentrations and are considered emerging environmental pollutants. However, their biological effects and the underlying mechanism remain unclear, especially alkyl-PFRs. In this study, a battery of in vitro bioassays was conducted to analyze the cytotoxicity, oxidative stress, mitochondrial impairment, DNA damage and the involved molecular mechanisms of several selected alkyl-PFRs.
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