JAM-A promotes wound healing by enhancing both homing and secretory activities of mesenchymal stem cells.

The homing ability and secretory function of mesenchymal stem cells (MSCs) are key factors that influence cell involvement in wound repair. These factors are controlled by multilayer regulatory circuitry, including adhesion molecules, core transcription factors (TFs) and certain other regulators. However, the role of adhesion molecules in this regulatory circuitry and their underlying mechanism remain undefined.

Selenium supplementation for sepsis: a meta-analysis of randomized controlled trials.

Background: Recently, several studies were conducted to investigate the effect of selenium supplementation in septic patients. However, no consistent conclusion was made. Thus, we aimed to systematically summarize the available randomized controlled trials (RCTs) to evaluate the effect of selenium supplementation on important clinical outcomes in septic patients.

Pre-hospital emergency burn management in Shanghai: analysis of 1868 burn patients.

Background: There are few studies reporting the level of pre-hospital emergency management of burn patients and related influencing factors in China. This study is a summary of our investigation on emergency education and people's awareness about pre-hospital emergency management of burn patients in Shanghai, China, and analyses key factors influencing pre-hospital emergency management of burn patients.

Methods: The survey was conducted by questionnaire in burn patients who sought initial clinical visits at the Burn Center of Changhai Hospital (Shanghai, China) between November 2009 and December 2010, including demographic data, burn conditions, pre-hospital emergency management and education about emergency burn management.

Characterization of nerve conduits seeded with neurons and Schwann cells derived from hair follicle neural crest stem cells.

In this study a tissue-engineered nerve conduit for repair of peripheral nerve defects was devised and characterized in vitro. To construct the nerve conduits, beagle sciatic nerves were acellularized with lysolecithin and seeded with neurons and Schwann cells, which were induced from rat hair follicle neural crest stem cells. The nerve constructs were cultured in vitro and characterized by multiple methods, including immnohistochemistry, electron microscopy, and electrophysiology at 1, 3, and 8 weeks.

Pluripotent hair follicle neural crest stem-cell-derived neurons and schwann cells functionally repair sciatic nerves in rats.

In this paper, we constructed a novel acellular nerve xenograft (ANX) seeded with neurons and Schwann cells to bridge long-distance gaps in rat sciatic nerves. The neurons and Schwann cells were induced from Sprague Dawley (SD) rat hair follicle neural crest stem cells with sonic hedgehog/retinoic acid and neuregulin 1, respectively. Fifty male SD rats were randomly divided into two groups (n = 25): ANX + cells group and ANX group.