Attitudes toward year-round influenza vaccination in pregnant women.

Influenza virus circulates year-round, yet uptake of maternal influenza vaccination decreases outside of influenza season. This prospective study of 62 pregnant women provides insight into the possible underlying reasons for this. Despite knowledge of benefits for maternal and infant outcomes, we observed a lack of understanding of rates of influenza infection outside influenza season, concerns about safety in relation to receiving multiple vaccinations during the same pregnancy, and lack of healthcare provider recommendation to be vaccinated outside influenza season.

An evaluation of strategies to achieve greater than 90% coverage of maternal influenza and pertussis vaccines including an economic evaluation.

Background: Maternal immunisation is an essential public health intervention aimed at improving the health outcomes for pregnant women and providing protection to the newborn. Despite international recommendations, safety and efficacy data for the intervention, and often a fully funded program, uptake of vaccines in pregnancy remain suboptimal. One possible explanation for this includes limited access to vaccination services at the point of antenatal care.

Combining phage display with SMRTbell next-generation sequencing for the rapid discovery of functional scFv fragments.

Phage display technology in combination with next-generation sequencing (NGS) currently is a state-of-the-art method for the enrichment and isolation of monoclonal antibodies from diverse libraries. However, the current NGS methods employed for sequencing phage display libraries are limited by the short contiguous read lengths associated with second-generation sequencing platforms. Consequently, the identification of antibody sequences has conventionally been restricted to individual antibody domains or to the analysis of single domain binding moieties such as camelid VHH or cartilaginous fish IgNAR antibodies.

Maternal vaccinations.

Background: Maternal immunisation, which refers to vaccinations administered during pregnancy, is an integral part of preventive healthcare for pregnant women and infants. With new maternal vaccines in development, the scope of maternal immunisation is expanding.

Objective: This review focuses on the principles underpinning maternal immunisation, the existing recommendations and maternal vaccines in development, a review of vaccines that may be indicated for pregnant women who wish to travel, and safety data on inadvertent administration of live vaccines to pregnant women.

Factors influencing the uptake of influenza vaccine vary among different groups in the hard-to-reach population.

Objective: This report describes a mobile outreach influenza immunisation program for vulnerable populations in a resource-rich setting. It explores vaccine recipients' demographics, comorbidities and vaccination histories, and the factors influencing their decision to receive vaccine during outreach.

Methods: Teams of nurse immunisers visited and provided influenza vaccines to clients from 21 sites (18 community centres for migrants, refugees and the homeless; and three outpatient clinics).

Myocarditis Caused by Human Parechovirus in Adult.

The infectious etiology of myocarditis often remains unidentified. We report a case of myocarditis associated with human parechovirus (HPeV) infection in an adult. HPeV is an emerging pathogen that can cause serious illness, including myocarditis, in adults.

Association of CYP2C19*2 polymorphism with clopidogrel response and 1-year major adverse cardiovascular events in a multiethnic population with drug-eluting stents.

Background: Patients undergoing elective percutaneous coronary intervention (PCI) with drug-eluting stents (DES) who have impaired clopidogrel response, have a higher risk of subsequent major adverse cardiovascular events (MACE).

Aim Of The Study: To establish the relationship between CYP2C19 genotype, clopidogrel responsiveness and 1-year MACE.

Materials & Methods: Aspirin/clopidogrel responses were assessed with Multiplate Analyzer and CYP2C19*2 allele by SpartanRx.