Hibernation Habitat Selection by the Threatened Chinese Softshell Turtle () in the Yellow River Wetlands of Northwest China: Implications for Conservation Management.

Hibernation is a crucial aspect of the life history of freshwater turtles inhabiting temperate regions. Therefore, understanding their hibernation habitat selection is essential for the targeted conservation of turtle species and their habitats. The Chinese softshell turtle (), a medium-sized freshwater turtle, is widely distributed in China; however, populations are rapidly declining, and threatened by habitat destruction, overfishing, and water pollution.

Lysosome-targeted dual-locked NIR fluorescent probe for visualization of HS and viscosity in drug-induced liver injury and tumor models.

Background: Lysosomes, as an indispensable subcellular organelle have numerous physiological functions closely associated with HS and viscosity, and accurate assessment of HS/viscosity fluctuations in lysosomes is essential for gaining a comprehensive understanding of lysosome-related physiological activities and pathological processes. The previous single-response fluorescent probes for either HS or viscosity alone have the potential to generate "false positive" signals in a complex biological environment. In contrast, dual-locked probes can simultaneously respond to multiple targets simultaneously, which could effectively eliminate this defect.

Cell-microsphere based living microhybrids for osteogenesis regulating to boosting biomineralization.

Biomineralization-based cell-material living composites showed great potential for living materials construction and cell regulation. However, cells in scaffolds with unconnected pores usually induce confined nutrient transfer and cell-cell communications, affecting the transformation of osteoblasts into osteocytes and the mineralization process. Herein, the osteoblast-materials living hybrids were constructed with porous PLLA microspheres using a rational design, in which cell-based living materials presented an improved osteoblast differentiation and mineralization model using rationally designed cell-microsphere composites.

Seasonality influences skin bacterial community structure and anti-Bd function in two anuran species.

Microorganisms on amphibian skin reduce disease susceptibility and play an important role in pathogen defense. We hypothesized that anuran skin bacterial communities would change in response to seasonal variation and host species. To test this hypothesis, we used 16S rRNA amplicon sequencing to identify cutaneous bacterial communities of two frogs from the Qinling Mountains of China, and .

Effects of Light Spectra on Nutritional Composition in Juvenile (Lamarck 1818) and Transcriptomic Analysis.

The razor clam , a commercially important and nutritionally valuable bivalve species, has been found to display notable responses to different light spectra. While previous research has highlighted the influence of light spectra on the growth, feeding rate, and various physiological characteristics of , its impact on the biochemical composition of this species remains unclear. Herein, we investigated the proximate, fatty acid, and amino acid compositions of cultured under various light spectra, including white, violet, blue, cyan, green, yellow, red, and darkness.

Dual-locked NIR fluorescent probe for detection of GSH and lipid droplets and its bioimaging application in cancer model.

Fluorescence probes with outstanding merits have wide applications in tumor diagnosis. However, most of these probes can only detect single tumor biomarker, potentially generating "false positive" signals within intricate biological systems. In contrast, the dual-locked fluorescent probes triggered by two response factors can effectively address the aforementioned limitations.

Air bag-embedded MIL-101(Fe) metal-organic frameworks for an amplified tumor microenvironment activation loop through strategic delivery of iron ions and lentinan.

Iron-based nanocarriers have demonstrated potential in redirecting tumor associated macrophages (TAMs) polarization towards the M1 phenotype, critical for activating the tumor microenvironment (TME) in triple negative breast cancer (TNBC). However, their real-world effectiveness is curtailed by insufficient Fe exposure and the absence of suitable synergists in tumors. We introduce an air bag-embedded iron-based MIL-101 metal-organic frameworks (MOF) for igniting the TME in TNBC through bubble-driven tumoral codelivery of Fe and lentinan.

Imaging of ONOO fluctuations during drug-induced liver/kidney injury and a dicyanoisophorone-based NIR fluorescent probe with a large Stokes shift.

Current clinical indicators for assessing liver/kidney injury are functional rather than injury indicators, which may cause some delays in the diagnosis of drug-induced liver injury (DILI) and kidney injury (DIKI). Therefore, the development of noninvasive and real-time methods for the effective diagnosis of DILI/DIKI is of great benefit to their clinical management. Herein, we constructed a dicyanoisophorone-based near-infrared (NIR) fluorescent probe (PNDP).

How can China tackle its declining fertility rate?

highlight the challenges and priorities for pronatalist policies and the health system amid declining fertility rates in China

Lactoferrin/CD133 antibody conjugated nanostructured lipid carriers for dual targeting of blood-brain-barrier and glioblastoma stem cells.

The main reasons for the difficulty in curing and high recurrence rate of glioblastoma multiforme (GBM) include: 1. The difficulty of chemotherapy drugs in penetrating the blood-brain barrier (BBB) to target tumor cells; 2. The presence of glioma stem cells (GSCs) leading to chemotherapy resistance.

Revealing the functional potential of microbial community of activated sludge for treating tuna processing wastewater through metagenomic analysis.

Reports regarding the composition and functions of microorganisms in activated sludge from wastewater treatment plants for treating tuna processing wastewater remains scarce, with prevailing studies focusing on municipal and industrial wastewater. This study delves into the efficiency and biological dynamics of activated sludge from tuna processing wastewater, particularly under conditions of high lipid content, for pollutant removal. Through metagenomic analysis, we dissected the structure of microbial community, and its relevant biological functions as well as pathways of nitrogen and lipid metabolism in activated sludge.

Targeted codelivery of doxorubicin and oleanolic acid by reduction responsive hyaluronic acid-based prodrug nano-micelles for enhanced antitumor activity and reduced toxicity.

Chemotherapy remains one of the most commonly used strategies in cancer treatment but suffers from damages to healthy tissues and organs. How to precisely co-deliver two or more drugs with different mechanisms of action to the tumors for synergistic function is a challenge for chemotherapy. Herein, Oleanolic acid (OA)-conjugated Hyaluronic acid self-assembled nano-micelles loaded with Doxorubicin (DOX) (HSO NPs/DOX) were constructed for CD44 positive cancer targeted codelivery of DOX and OA.

Nitroxide radical conjugated ovalbumin theranostic nanosystem for enhanced dendritic cell-based immunotherapy and T magnetic resonance imaging.

Melanoma, known for its aggressive metastatic nature, presents a formidable challenge in cancer treatment, where conventional therapies often fall short. This study introduces a pioneering approach utilizing metal-free nanosystem as tumor vaccines, spotlighting their potential in revolutionizing melanoma treatment. This work employed organic nitroxides, specifically 4-carboxy-TEMPO, in combination with chitosan (CS), to create a novel nanocomposite material - the CS-TEMPO-OVA nanovaccines.

Environmental exposure patterns to 94 current-use pesticides in women of reproductive age who are preparing for pregnancy.

Current-use pesticides (CUPs), including insecticides, fungicides, and herbicides, are extensively employed in agriculture to manage pests, diseases, and weeds. Nonetheless, their widespread application raises significant concerns regarding potential impacts on human health, particularly with reproductive health. This study focuses on exploring the landscape of CUP exposure among pre-pregnancy women.

Construction and Preliminary Evaluation of Two F-Labeled Radiopharmaceuticals for Myocardial Perfusion Imaging.

Aims: PET myocardial perfusion imaging (MPI) is the gold standard for the noninvasive diagnosis of ischemic myocardial. Construction of F-labeled PET MPI probe showed benefits to reduce the imaging cost, and enhance the image quality and patient-friendliness.

Methods: Two F-labeled MPI probes (F-BoMPI) were developed.

Development of a Supermolecular Radionuclide-Drug Conjugate System for Integrated Radiotheranostics for Non-small Cell Lung Cancer.

Radionuclide-drug conjugates (RDCs) designed from small molecule or nanoplatform shows complementary characteristics. We constructed a new RDC system with integrated merits of small molecule and nanoplatform-based RDCs. Erlotinib was labeled with I to construct the bulk of RDC (I-ER).

Alkali and alkaline earth elements in follicular fluid and the likelihood of diminished ovarian reserve in reproductive-aged women: a case‒control study.

Background: Imbalances in alkali elements (AEs) and alkaline earth elements (AEEs) cause reproductive disorders. However, it remains unclear whether AEs/AEEs in follicular fluid have a relationship with the serious reproductive disorder known as diminished ovarian reserve (DOR).

Methods: A nested case‒control study was carried out in China.

Bacterial community analysis of the skin microbiota of cultured Chinese giant salamander infected with .

Skin microorganisms are an important component of host innate immunity and serve as the first line of defense against pathogenic infections. The relative abundance of bacterial species, microbial community assembly, and secretion of specific bacterial metabolites are closely associated with host health. In this study, we investigated the association between the skin microbiome and , and compared the bacterial community assemblage, alpha and beta diversity, and functional predictions of the skin bacterial assemblage in cultured healthy Chinese giant salamanders () and individuals infected with Chinese giant salamander iridovirus (GSIV or ADRV).

Rotational Load Fatigue Performance of a One-Size Implant- Abutment Connection System.

Purpose: To investigate the rotational load fatigue performance of different implant diameters and abutment platforms of a one-size implant-abutment (OSIA) connection system.

Materials And Methods: Narrow-, regular-, and wide-diameter implants were tested with regular base (RB/WB) abutments of an OSIA system (BLX, Straumann). Wide-diameter implants (WDIs) were also tested with wide base (WB) abutments.

Self-Stimulated Photodynamic Nanoreactor in Combination with CXCR4 Antagonists for Antileukemia Therapy.

The treatment of acute myeloid leukemia (AML) remains unsatisfactory, owing to the absence of efficacious therapy regimens over decades. However, advances in molecular biology, including inhibiting the CXCR4/CXCL12 biological axis, have introduced novel therapeutic options for AML. Additionally, self-stimulated phototherapy can solve the poor light penetration from external sources, and it will overcome the limitation that traditional phototherapy cannot be applied to the treatment of AML.

Federated attention consistent learning models for prostate cancer diagnosis and Gleason grading.

Artificial intelligence (AI) holds significant promise in transforming medical imaging, enhancing diagnostics, and refining treatment strategies. However, the reliance on extensive multicenter datasets for training AI models poses challenges due to privacy concerns. Federated learning provides a solution by facilitating collaborative model training across multiple centers without sharing raw data.