Intranasal Ion-Triggered In Situ Delivery System of Virus-like Particles: Development Using the Quality by Design Approach.

The rapid growth in the prevalence of infectious diseases requires timely action from drug developers. In recent years, the COVID-19 pandemic has demonstrated the unpreparedness of the population for such emergencies. The introduction of modern methods of Design of Experiments (DoE) is required to accelerate the process of drug development and bring a drug to market.

Main Aspects of Pharmaceutical Development of Immunobiological Drugs for Intranasal Administration.

Introduction: The review presents the latest developments in the area of intranasal in situ delivery systems of immunobiological drugs (IBDs). Interest in intranasal administration for IBDs has increased significantly due to the COVID-19 pandemic. However, not only intranasal delivery of vaccines is developing, but also bacteriophages, interferons, etc.

[ gels as a modern method of intranasal vaccine delivery].

The continuous emergence of new pathogens and the evolution of microbial drug resistance make it absolutely necessary to develop innovative, effective vaccination strategies. Use of nasal vaccination can increase convenience, safety, cause both local and systemic immune reactions. Intranasal administration nevertheless has a number of shortcomings that can be overcome by using the latest achievements of pharmaceutical science.

[Taxonomic Genetics of Methylotrophic Yeast Genus Komagataella: New Biological Species K. kurtzmanii].

Genetic hybridization analysis revealed that industrially important species Komagataella kurtzmanii has re productive postzygotic isolation from K. pastoris, K. populi, K.

[Hybrid Sterility of the Yeast Schizosaccharomyces pombe: Genetic Genus and Many Species in statu nascendi?].

A phenomenon of ascospore death was observed in a number of Schizosaccharomyces pombe interstrain hybrids. Meiotic recombination of the control parental auxotrophic markers was, however, observed in a random ascospore analysis. Genetic and molecular biological data indicated existence of at least geographical divergence of the genomes in Sch.

Natural polyploidization of some cultured yeast Saccharomyces sensu stricto: auto- and allotetraploidy.

Using genetic and flow cytometric analyses, we showed that wine strain S6U is an allotetraploid of S. cerevisiae x S. bayanus.