Juvenile idiopathic arthritis with systemic onset with inflammatory bone lesions: two case reports of patients successfully treated with canakinumab and experience gained from literature.

Unlabelled: Non-bacterial osteomyelitis (NBO) is a rare chronic inflammatory bone disease related to immune system dysregulation. This disease belongs to a family of autoinflammatory diseases. It often coexists with other TNF-α-mediated immune-mediated diseases such as juvenile idiopathic arthritis (JIA) and inflammatory bowel diseases.

[ASYMPTOMATIC INTRAHEPATIC CHOLANGIOCARCINOMA].

Objective: To analyze the cases of intrahepatic cholangiocarcinoma posthumous diagnosis in patients with concomitant atherosclerotic lesions of the femoral arteries. Key points: The present report describes the clinical observation of a rare tumor - intrahepatic cholangiocarcinoma. Difficulties of its early diagnosis is a combination of symptoms of tumor progression with pain in the lumbar spine, the latter in the presence of concomitant femoral arteries of atherosclerotic lesions, characterized by pain similar localization has led to delay cancer research.

[Formation of probabilistic structure of motor behavior in bottlenose dolphins in captivity].

A probabilistic structure of the motor behavior was analyzed in dolphin calves Tursiops truncatus in the prenatal period and adult dolphins in an oceanarium. Ethograms were recorded and subjected to a computer analysis. Ranking probabilities of transitions between behavioral acts revealed a highly determined sequence of operations underlying the newborn dolphins' behavior.

[Diagnosis of left-ventricular diastolic dysfunction in patients with predialysis chronic renal failure].

Aim: To specify effectiveness of different methods for assessment of diastolic function in patients with pre-dialysis chronic renal failure (CRF).

Material And Methods: Forty non-diabetic pre-dialysis CRF patients (20 males and 20 females, mean age 51 +/- 11 years) were studied. Serum creatinine was 209.

[Use of ceramic endoprostheses in reconstructive surgery of the lower jaw in children].

The work analyses the possibility to use individually prepared ceramic endoprostheses in 6 children with a congenital or acquired pathology of the mandible. The operative methods with the application of ceramic endoprostheses are described which are characterized by less traumatic action and higher accuracy of correcting the defect or deformity of the mandible as compared with using biological plastic materials. This method of treatment can be recommended at the intermediate stages of the restorative reconstruction treatment of the mandible pathology in children.

[Impact of day-to-day arterial pressure variability on the left ventricle geometry in patients with predialysis chronic kidney insufficiency].

Aim: To estimate the impact of day-to-day variability of blood pressure (BP) on left ventricular geometry in pre-dialysis patients.

Material And Methods: We estimate the impact of day-to-day variability of BP on left ventricular geometry in 42 non-diabetic pre-dialysis patients (22 F, 20 M, mean age 47 +/- 12 years) with arterial hypertension (> 140 and 90 mm Hg). Serum creatinine was 286.

[Effects of arterial compliance on geometry of the left ventricle in patients with pre-dialysis chronic renal failure].

To examine relationships between left ventricular geometry and general arterial compliance (GAC) in patients with predialysis chronic renal failure (CRF). 102 patients with predialysis CRF unrelated to diabetes mellitus (males 46, females 56, mean age 49.1 +/- 18.

[Treatment of local Hodgkin's disease with massive mediastinal involvement].

Aim: To define the scope of combined therapy in patients having local Hodgkin's disease (LHD) with massive mediastinal lesion.

Material And Methods: From 1980 to 1997 the treatment was given to 75 LHD patients with massive lesion of the mediastinum (mediastinal-thoracic index, MTI, > or = 0.33).

[Heart remodeling in patients with predialysis phase of chronic renal failure].

Aim: To investigate remodeling of the heart in patients with predialysis phase of chronic renal failure (CRF).

Material And Methods: Patients with predialysis phase of CRF (n = 61; serum creatinine 412.4 +/- 242.

[Superhigh-dosage chemotherapy with the transplantation of autologous hemopoietic precursor cells in patients with a prognostically unfavorable relapse and resistant course of lymphogranulomatosis].

Eighteen patients with relapsed or refractory Hodgkin's disease (HD) have been treated with high-dose chemotherapy (BEAM regimen) followed by autologous peripheral stem cells and/or bone marrow rescue. There were no treatment-related deaths. Overall response rate was 82%.

[Lipid peroxidation and the trace element content of the blood in patients with lichen ruber planus of the oral mucosa].

Examinations of 143 patients with lichen planus of the buccal mucosa and of 45 normal subjects included studies of lipid peroxidation (LPO) activity and of anti-radical defence system, as well as measurements of a number of blood trace elements. Plasma and red cell LPO intensity in the patients was several times higher than in the controls. Plasma glutathione peroxidase activity was found essentially reduced in the patients, whereas in red cells this activity surpassed 5 times the normal values.

[The combined therapy of stage-II lymphogranulomatosis: the effect of splenectomy and the time period for achieving full remission on treatment efficacy].

In 1982-1986, 72 patients with stage II lymphogranulomatosis received combined treatment according to the following program: 3 cycles of polychemotherapy in accordance with the CVPP scheme plus radiation of all the lymphatic collectors above the diaphragm up to the total radiation dose 35 Gy plus 3 cycles according to the CVPP. Splenectomy was provided to 45 patients; spleen impairment was revealed in 13. The median observation period reached 67 months.

[Comparative evaluation of radiotherapy and chemoradiotherapy in inoperable cancer of the esophagus].

The paper is concerned with the results of radiation therapy and three variants of chemoradiotherapy of 174 patients with inoperable esophageal cancer. Altogether 151 (87%) patients were given treatment from beginning to end. Complete tumor regression was noted in 41% of the patients after chemoradiotherapy and in 29%--after radiotherapy.

[The polychemotherapy and combined treatment of patients with stage-I and -II lymphogranulomatosis and unfavorable prognosis].

As many as 104 patients with lymphogranulomatosis, clinical stages I-II, having an unfavourable prognosis were examined for the efficacy of polychemotherapy and combined treatment. Polychemotherapy was received by 47 patients, combined treatment (chemo- plus radiotherapy) by 57 patients. Complete remissions were attained significantly more often in patients given combined treatment (92%) as compared to patients on polychemotherapy alone (64%).

[Biological properties of glutamin-(asparagin-)ase from Pseudomonas boreopolis 526].

Glutamine(asparagine)ase from Ps. boreopolis 526 has an antineoplastic effect on lymphoid leukemia P-388. The enzyme half-life in the mouse serum is 8.

[Comparative evaluation of the clinical effectiveness of 3 preparations of E. coli L-asparaginase].

Preparations of L-asparaginase made in the USSR, FRG and Japan were studied comparatively in 277 patients with acute lymphoblastic leukemia and lymphosarcomas. It was shown that the clinical characteristics of the preparation made in the USSR and the preparation (crasnitin) made in the FRG were identical. By the antileukemic action the preparation made in the USSR was superior to the preparation (leunase) made in Japan in the treatment of adult patients with such hemoblastosis forms.

[Use of preparation VM 26 (epipodophyllotoxin) for treating lymphomas in children and adults].

A coordinated clinical trial (phase II) of preparation VM-26 supplied by Sandos (Switzerland) was carried out at 5 clinics in a total of 61 patients with lymphoma. Two regimens of VM-26 administration were employed: (1) 5-day courses of 30 mg/m2 iv with 7-14 day intervals, or (2) two injections of 50 mg/m2 a week, within 4-6 weeks, depending on drug tolerance Out of 15 children with Hodgkin's disease, 50% of cases showed complete or partial remission. Out of 27 adults with Hodgkin's disease, response was registered in 69.