Publications by authors named "Kondoh T"

To evaluate oxidative stress involved in Down syndrome periodontal disease and pathological premature aging, reactive oxygen species (ROS) such as superoxide (O) and hydroxyl radical (HO) in human saliva were measured using electron spin resonance (ESR) spectroscopy. The groups consisted of 20 subjects in the Down syndrome (DS) child (DC) group (mean age 11.3 ± 4.

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  • Proximal renal tubular dysfunction is common during diabetic ketoacidosis (DKA) in newly diagnosed type 1 diabetes, but previous studies have lacked comprehensive analysis of its multiple functions and have not explored distal tubular function.
  • In a study involving patients with and without DKA, those with DKA showed significantly higher levels of urinary β2-microglobulin and lower blood pH and phosphorus reabsorption, indicating renal dysfunction.
  • The findings suggest that DKA in type 1 diabetes may lead to multiple proximal tubular dysfunctions resembling transient Fanconi syndrome, while distal renal tubular acidosis is unlikely to be present.
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Transarterial embolization using Onyx (Medtronic, Irvine, CA, USA) results in a high cure rate for complete obliteration of dural arteriovenous fistulas. However, incomplete obliteration occurs in some cases. Reports on the use of bailout therapy in such cases are limited.

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Internal carotid artery dissection is rare but can be a cause of stroke in young people. In a case of revascularization for stroke associated with internal carotid artery dissection, we initially used a stent retriever for thrombectomy. Since an appropriately-sized stent for permanent treatment was not available, we innovatively maintained temporary revascularization with the stent retriever for 90 minutes.

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A 69-year-old woman was diagnosed with an asymptomatic intracranial tumor nine years ago and has been followed with annual MR imaging studies. Two years ago, the tumor had grown in size, requiring treatment. She experienced ophthalmopathy due to hyperthyroidism 27 years ago and was treated with 20 Gy in 10 fractions using parallel opposed beams to her bilateral posterior eyeballs, supplemented with steroid pulse therapy.

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A 73-year-old female developed right facial paralysis of House-Brackmann (H-B) grade III and was diagnosed with Bell's palsy. After three months of steroid therapy, she developed progressive hearing loss, and an MRI revealed a tumor in the right internal auditory canal. Within a few months, the right facial nerve palsy recurred, and the patient was treated with Gamma Knife radiosurgery.

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Dried bonito dashi, a complex mixture of sour, bitter, and umami substances as well as over 400 odorants, is the most widely used Japanese fish broth that enhances palatability of various dishes. Recent studies have suggested that prior experience with dried bonito dashi produces strong enhancement of subsequent intake and preference for dried bonito dashi. The present study investigated taste substances in dried bonito dashi that enhance subsequent dashi preference by its prior exposure.

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Background: The immunosuppressant mizoribine (Miz) can reduce progression of childhood IgA nephropathy (IgAN). This study examined whether Miz affects CD163 M2-type macrophages which are associated with kidney fibrosis in childhood IgAN.

Methods: A retrospective cohort of 90 children with IgAN were divided into groups treated with prednisolone (PSL) alone (P group; n = 42) or PSL plus Miz (PM group; n = 48) for a 2-year period.

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A right-sided aortic arch (RAA) is a rare variant of the aortic arch found. We present a case of endovascular treatment (EVT) for acute basilar artery (BA) occlusion with an RAA. A 70-year-old man developed acute ischemic stroke due to BA occlusion.

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  • * A case study of a nine-month-old boy revealed that he suffered from refractory nephrotic syndrome and complications from spTMA, along with a heterozygous mutation in the complement factor-I gene and a deletion affecting complement regulation.
  • * Despite treatment with Eculizumab, which temporarily improved his condition, the boy experienced severe complications including cardiac arrest and was later declared brain dead, highlighting the diagnostic difficulties and the complex interplay between
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Alport syndrome is a hereditary disorder characterized by renal impairment, hearing loss, and ocular symptoms and is caused by COL4A3, COL4A4, and COL4A5 mutations. Here, we report the case of 3-year-old boy with isolated hematuria detected in routine preventative urinary screening conducted in 3-year-old children. He carried a novel variant, NM_033380.

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Background: Cauda equina tumors are rare primary spinal tumors. Histologically, the most common tumor arising from the cauda equina is a schwannoma. However, little is known about the long-term postoperative outcomes of cauda equina schwannoma.

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  • Down syndrome (DS), caused by trisomy 21, has seen increased prevalence and life expectancy due to factors like maternal age and medical advancements.
  • Research identifies hematological abnormalities in adult DS individuals, including leukopenia (low white blood cell count), macrocytosis (enlarged red blood cells), and thrombocytopenia (low platelet count).
  • These hematological issues appear more frequently with age, suggesting a need for further studies to understand aging-related disorders in DS and the general population.
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Background And Purpose: To assess the long-term outcomes of intracranial dural arteriovenous fistula (DAVF) treated with stereotactic radiosurgery (SRS) alone or embolization and SRS (Emb-SRS) and to develop a grading system for predicting DAVF obliteration.

Methods: This multi-institutional retrospective study included 200 patients with DAVF treated with SRS or Emb-SRS. We investigated the long-term obliteration rate and obliteration-associated factors.

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Type 3 renal tubular acidosis is a pathological condition characterized by the simultaneous occurrence of distal renal tubular acidosis, which causes urinary acidification disorders, and proximal renal tubular acidosis, which causes impaired reabsorption of bicarbonate ions. Type 3 renal tubular acidosis is considered rare. A 5-year-old boy was admitted to our hospital because of frequent vomiting, poor vitality, and fever.

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Objective: Radiotherapy has an essential role in the management of skull base chondrosarcomas (SBCs) after resection. This multi-institutional study evaluated the outcomes of Gamma Knife radiosurgery (GKRS) for histopathologically proven SBCs.

Methods: Data of patients who underwent GKRS for SBCs at Gamma Knife centers in Japan were retrospectively collected.

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A 13-year-old boy, with a history of intermittent headache and transient diplopia, was found to have non-hemorrhagic cerebral arteriovenous malformation in the midbrain tegmental region associated with hydrocephalus. Gamma knife radiosurgery was performed at 16 Gy with 75% marginal dose. Posttreatment course was uneventful.

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  • Carbon fiber-reinforced plastic (CFRP) structures can suffer from hidden impact damage that significantly weakens their mechanical properties, highlighting the need for effective monitoring systems.
  • This study developed a structural health monitoring (SHM) system using ultrasonic guided waves, generated by a broadband chirp signal from a piezoelectric actuator, to detect and evaluate impact damage in CFRP materials.
  • The research showed a linear relationship between the size of impact damage and the maximum time-of-flight (ToF) delay for various CFRP plate types, indicating that this SHM technique can effectively quantify damage size and extent.
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  • * A 13-year-old Japanese girl experienced diabetic ketoacidosis and poor insulin secretion, but improved after starting insulin treatment, requiring no further treatment for 2 years until a recurrence occurred at age 15.
  • * The ongoing fluctuations in her insulin production suggested MODY, yet her case deviates from typical MODY8 presentations as it showed no exocrine dysfunction despite having a significant mutation in the CEL gene, indicating a potential link between her specific mutation
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Soft tissue calcifications are common findings in patients with various diseases, such as malignant tumors, collagen diseases, trauma, and chronic kidney disease. The majority of these lesions are not clinically significant; however, they can cause specific disorders within a limited space, such as the spinal canal. Here, we report the case of a patient undergoing fusion surgery for lumbar canal stenosis due to degenerative spondylolisthesis and multiple intraspinal canal calcifications associated with psoriatic arthritis (PsA).

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We report three cases in which endovascular treatment (EVT) was performed for anterior circulation large vessel occlusion (LVO) beyond 24 h from the onset of stroke. Case 1 experienced left hemispatial neglect and gait disorder due to right internal cerebral artery (ICA) occlusion and underlying atherosclerosis. After percutaneous transluminal angioplasty (PTA), revascularization with mild stenosis was achieved.

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Ostial common carotid artery (CCA) stenosis is rare, compared to extracranial internal carotid artery bifurcation lesions. In cases of a tandem lesion, the proximal lesion usually involves the extracranial internal carotid artery, and the ostial CCA is rarely implicated. A 69-year-old woman who underwent 3 months of antiplatelet therapy for asymptomatic, right ostial, severely calcified CCA stenosis presented with sudden onset left hemiparesis.

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Introduction: Highly sensitive reagents for detecting SARS-CoV-2 antigens have been developed for accurate and rapid diagnosis till date. In this study, we aim to clarify the frequency of false-positive reactions and reveal their details in SARS-CoV-2 quantitative antigen test using an automated laboratory device.

Methods: Nasopharyngeal swab samples (n = 4992) and saliva samples (n = 5430) were collected.

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Leptomeningeal metastases (LM) may complicate the clinical course of any solid cancer or hematological malignancy. Diagnosis of such cases requires a multifaceted approach, including careful evaluation of the clinical history, detailed neurological examination, advanced imaging studies, and related laboratory data analysis. Therapeutic options for management of LM have not been standardized yet.

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