Morbidity profile of the patients attending Mobile Medical Unit camps in Telangana: A record-based study.

Mobile Medical Units (MMUs) are one of the major initiatives under the National Rural Health Mission. These MMUs help people in remote, underserved areas access healthcare at affordable prices on their doorstep. The present record-based study aimed to assess the morbidity profile of the patients attending Mobile Medical Unit camps in the Yadadri-Bhuvanagiri district between April 2022 and December 2022.

Burden and awareness of anemia among adolescent girls of residential school in Telangana.

Objectives: Adolescence is an important transition phase and the burden of anemia among adolescent school-going children is not well explored. The present study was carried out to determine the prevalence of anemia among school-going adolescent girls and to explore their awareness on anemia.

Methods: A cross-sectional study was conducted among 217 adolescent girls studying in a residential school of Bibinagar village, Telangana.

Isolation of human antibodies against influenza B neuraminidase and mechanisms of protection at the airway interface.

Influenza B viruses (IBVs) comprise a substantial portion of the circulating seasonal human influenza viruses. Here, we describe the isolation of human monoclonal antibodies (mAbs) that recognized the IBV neuraminidase (NA) glycoprotein from an individual following seasonal vaccination. Competition-binding experiments suggested the antibodies recognized two major antigenic sites.

Evaluation of risk factors for non-alcoholic fatty liver disease in India: A systematic review and meta-analysis.

Introduction: NAFLD is emerging as an important cause of liver disease in India. It is estimated that 16-32% of general population in India (nearly 120 million) has NAFLD.

Objective: This study aimed to identify the risk factors of NAFLD and to identify the association of lifestyle (dietary and physical activity), genetic, and environmental factors with NAFLD in India.

Review of Primary Care Treatment Protocols for Hypertension in Various States of India.

Over the past few decades, hypertension (HTN) has affected both young and old people. The public health problem has an enormous economic impact on societies as well. The present review aimed to understand and compare the differences from the available literature on HTN treatment at the primary care level in various states and at the national level in India.

Sulfur-Directed C-Selective Alkenylation of Indoles under Rhodium Catalysis.

Regioselective direct functionalization of an indole benzenoid fragment has been a significant challenge because of its inherently lower reactivity. In this report, we introduce a Rh-catalyzed C-selective alkenylation of indole derivatives using a new sulfur directing group -SCy. A notable feature of this system is that the directing group is readily installed to the indoles and easily removed after the catalysis under mild conditions.

Thioether-Directed C4-Selective C-H Acylmethylation of Indoles Using α-Carbonyl Sulfoxonium Ylides.

Site-selective direct functionalization of an indole benzenoid core has been a great challenge due to its inherently poor reactivity. We herein demonstrate an iridium-catalyzed C4-selective acylmethylation of indoles using α-carbonyl sulfoxonium ylides as carbene precursors. This method exhibits high efficiency and broad functional group compatibility.

Iridium-Catalyzed Direct C4- and C7-Selective Alkynylation of Indoles Using Sulfur-Directing Groups.

Indoles and their analogues have been one of the most ubiquitous heterocycles during the past century, and extensive studies have been conducted to establish practical synthetic methods for their derivatives. In particular, selective functionalization of the poorly reactive benzenoid core over the pyrrole ring has been a great challenge. Reported herein is an iridium-catalyzed direct alkynylation of the indole C4- and C7-positions with the assistance of sulfur directing groups.

Thioether-Directed Selective C4 C-H Alkenylation of Indoles under Rhodium Catalysis.

A thioether-directed Rh(III)-catalyzed C4 selective C-H alkenylation of indoles via the formation of 5-membered metallacycle intermediates is reported. This protocol allows a wide functional group compatibility and broad substrate scope. The directing group can be readily removed or transformed into other functional groups after the C-H functionalization event.

The NEU1-selective sialidase inhibitor, C9-butyl-amide-DANA, blocks sialidase activity and NEU1-mediated bioactivities in human lung in vitro and murine lung in vivo.

Neuraminidase-1 (NEU1) is the predominant sialidase expressed in human airway epithelia and lung microvascular endothelia where it mediates multiple biological processes. We tested whether the NEU1-selective sialidase inhibitor, C9-butyl-amide-2-deoxy-2,3-dehydro-N-acetylneuraminic acid (C9-BA-DANA), inhibits one or more established NEU1-mediated bioactivities in human lung cells. We established the IC50 values of C9-BA-DANA for total sialidase activity in human airway epithelia, lung microvascular endothelia and lung fibroblasts to be 3.

Gold(I)-catalyzed hydroindolylation of allenyl ethers.

The gold(i)-catalyzed reaction/rearrangement of allenyl ethers has been investigated in the presence of indoles. Either hydroindolylation or alkylation of an indole with the pendant group of allenyl ether has been observed. The reaction outcome seems to be decided mainly by the nature of the pendant group of the allenyl ether.

A simple method for the preparation of ultra-small palladium nanoparticles and their utilization for the hydrogenation of terminal alkyne groups to alkanes.

A simple and convenient method for the preparation of ultra-small palladium nanoparticles (Pd-NPs) by a modified digestive ripening method is described. These nanoparticles catalyse the hydrogenation of the terminal alkyne groups to alkanes selectively, and show no effect on other labile protecting and internal alkyne or internal/external alkene groups present in the molecule.

Gold(I)-catalysed [1,3] O→C rearrangement of allenyl ethers.

A simple and rapid access to the α-substituted acryl aldehydes has been provided by developing a gold-catalysed [1,3] rearrangement of the allenyl ethers importantly with a record turnover frequency of 4600 h(-1) (at 0.05 mol% of the catalyst concentration) in homogeneous gold(I) catalysis.