Endoscopic Calcaneoplasty With Bony Debridement and Radiofrequency.

Haglund's deformity refers to the enlargement of the posterosuperior tuberosity of the calcaneus, which can cause debilitating posterior heel pain and swelling. Calcaneoplasty is indicated for the treatment of Haglund's deformity following a failure of conservative treatment. Endoscopic calcaneoplasty confers a few advantages over open surgery and has been growing in popularity as the preferred technique.

Suspensory Device Fixation of Lisfranc Injuries in a Southeast Asian Urban Population: Patient-Reported Functional Outcomes.

Introduction Open reduction internal fixation (ORIF) and primary arthrodesis are two conventional options for the treatment of Lisfranc injuries. However, they are associated with implant-related complications. An alternative suspensory device construct using interosseous nonabsorbable sutures with endobuttons has been described with satisfactory results.

Rhabdomyolysis Masquerading as Cauda Equina Syndrome.

Lower back pain is a very common presenting condition, with a large proportion resulting from discogenic causes, especially after strenuous activity. In patients with a history of exertion, lower back pain, and acute urinary retention, the obvious diagnosis to exclude would be cauda equina syndrome. We present a case of a 32-year-old man who presented with lower back pain, bilateral lower limb weakness, and acute urinary retention following a recent episode of heavy lifting.

Roadmap Out of COVID-19.

The recent coronavirus disease (COVID-19) was declared as a public health emergency by the World Health Organisation on 30th January 2020, and has now affected more than 100 countries. Healthcare institutions and governments worldwide have raced to contain the disease, albeit to varying degrees of success. Containment strategies adopted range from complete lockdowns to remaining open with public advisories regarding social distancing.

Intraocular beta-radiation for proliferative vitreo-retinopathy.

Proliferative vitreoretinopathy (PVR) is the most common cause of failure in retinal detachment surgery. PVR is a result of an enhanced healing process. Various surgical and pharmacological methods have failed to provide a definite solution to the problem.

Early controlled drainage of massive suprachoroidal hemorrhage with the aid of an expanding gas bubble and risk factors.

Purpose: To assess the visual outcome after massive suprachoroidal hemorrhage managed by early controlled drainage using the aid of an intravitreal expanding gas bubble (100% perfluoropropane). The ocular and systemic risk factors were also reviewed.

Methods: Data were obtained retrospectively from patients with massive suprachoroidal hemorrhage who were treated in Worthing and Southlands National Health Service Trust between January 2003 and December 2008.

Reopening of a macular hole after nd:yag laser capsulotomy in a vitrectomized eye.

Purpose: To describe a case of reopening of macular hole in a vitrectomized eye after Nd:YAG laser capsulotomy.

Methods: A 70-year-old man presented with a Stage 3 macula hole 5 years previously with a vision of 6/24.

Results: The patient had a vitrectomy with perfluoropropane tamponade.

Visual function following transpupillary thermotherapy with adjusted laser parameters for the treatment of exudative age-related macular degeneration: a pilot study.

Purpose: To evaluate the efficacy of transpupillary thermotherapy (TTT) using adjusted laser parameters for the treatment of choroidal neovascularization (CNV) secondary to age-related macular degeneration.

Methods: TTT was performed on patients with CNV using a diode laser (810 nm) for 60 s in a subthreshold manner. Power settings were varied between 460 and 1200 mW, depending on lesion size, presence of pigment epithelial detachment and the amount of fundal pigmentation and subretinal fluid.

Macular hole surgery without prone positioning.

Purpose: To investigate the role of vitrectomy without prone posturing in the anatomic and functional outcome of macular hole surgery (MHS).

Methods: Forty-one consecutive eyes of 41 patients with stage II-IV full-thickness macular holes underwent pars plana vitrectomy and 16% C3F8 tamponade. In 25 cases posturing group (P), subjects were instructed to assume prone positioning for 10 days postoperatively, whereas in 16 cases non-posturing group (NP) patients were advised to avoid lying supine but no other posturing instructions were given.

Developmental roles of the Mi-2/NURD-associated protein p66 in Drosophila.

The NURD and Sin3 histone deacetylase complexes are involved in transcriptional repression through global deacetylation of chromatin. Both complexes contain many different components that may control how histone deacetylase complexes are regulated and interact with other transcription factors. In a genetic screen for modifiers of wingless signaling in the Drosophila eye, we isolated mutations in the Drosophila homolog of p66, a protein previously purified as part of the Xenopus NURD/Mi-2 complex.

Silicone oil concentrates fibrogenic growth factors in the retro-oil fluid.

Aim: To determine whether silicone oil concentrates protein and growth factors in the retro-oil fluid.

Methods: A laboratory analysis of intraocular fluid and vitreous specimens obtained from patients undergoing removal of silicone oil, revision vitrectomy, or primary vitrectomy for macular hole, proliferative vitreoretinopathy (PVR), or retinal detachment. Patients were prospectively recruited from routine vitreoretinal operating lists.

Transpupillary thermotherapy for the treatment of subfoveal choroidal neovascularization associated with age-related macular degeneration.

Objective: To evaluate the efficacy of transpupillary thermotherapy (TTT) for the treatment of choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD).

Design: Prospective, non-randomized, non-masked, case-selected series.

Methods: All patients with subfoveal CNV due to AMD and initial visual acuity (VA) between 6/9 and 6/60 were offered the opportunity to undergo TTT.

Germ-line specific variants of components of the mitochondrial outer membrane import machinery in Drosophila.

A search of the Drosophila genome for genes encoding components of the mitochondrial translocase of outer membrane (TOM) complex revealed duplication of genes encoding homologues of Tom20 and Tom40. Tom20 and Tom40 were represented by two differentially expressed homologues in the Drosophila genome. While dtom20 and dtom40 appeared to be expressed ubiquitously, the second variants, called tomboy20 and tomboy40, were expressed only in the male germ-line.

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

The link between basal cell carcinoma (BCC) and aberrant activation of the Hedgehog (Hh) signaling pathway has been well established in humans and in mouse models. Here we report the development of assays, including two novel in vitro BCC models, which allowed us to screen for Hh inhibitors and test their validity as potential treatments for BCC. We identified a novel small molecule Hh inhibitor (CUR61414) that can block elevated Hh signaling activity resulting from oncogenic mutations in Patched-1.

Matrix metalloproteinases: a role in the contraction of vitreo-retinal scar tissue.

The most common cause of failure of retinal reattachment surgery is formation of fibrocellular contractile membranes on both surfaces of the neuroretina. This intraocular fibrosis, known as proliferative vitreoretinopathy, results in a blinding tractional retinal detachment because of the contractile nature of the membrane. Contractility is a cell-mediated event that is thought to be dependent on locomotion and adhesion to the extracellular matrix.

How to predict proliferative vitreoretinopathy: a prospective study.

Purpose: To determine prospectively the accuracy of a predictive risk formula for the development of postoperative proliferative vitreoretinopathy (PVR) when applied in a clinical setting.

Design: Prospective noncomparative interventional case series.

Participants: Two hundred nineteen subjects undergoing primary vitrectomy for rhegmatogenous retinal detachment were studied.

Adjuvant 5-fluorouracil and heparin prevents proliferative vitreoretinopathy : Results from a randomized, double-blind, controlled clinical trial.

Purpose: To assess the safety and efficacy of adjuvant combination therapy using 5-fluorouracil (5-FU) and low molecular weight heparin (LMWH) for prevention of proliferative vitreoretinopathy (PVR) after vitrectomy and retinal reattachment surgery.

Design: Prospective randomized, double-masked, placebo controlled trial.

Participants: One hundred seventy-four high-risk patients were randomized to receive either 5-FU and LMWH therapy or placebo.