Pathophysiology of the ototoxicity of cis-diamminedichloroplatinum.

The electrophysiologic and histopathologic changes in the inner ear caused by the administration of cis-diamminedichloroplatinum (CP) were studied in guinea pigs. The endocochlear dc potential (EP) gradually decreased after the intravenous injection of CP and reached approximately 0 mV on the fourth day, but the EP did not become negative. The cochlear microphonics also diminished and could not be recorded on the fourth day.

Laryngeal angiomyoma (vascular leiomyoma): clinicopathological findings.

Two cases of laryngeal angiomyoma which developed in 51 and 52-year-old men are reported. One was a tumor found in the supraglottic area of the larynx and the other was in the subglottic space. Each was a spherical tumor with a smooth surface.

Vestibular fenestration and stapedioplasty in congenital stapes and vestibular window abnormality.

In this paper the results of vestibular fenestration and stapedioplasty in cases of congenital stapes deformity and vestibular window abnormality are presented. The problems in the surgical reconstruction of the middle ear transmission system, especially the importance of the areal ratio between the tympanic membrane and the vestibular window and the ossicular lever action, are discussed. The following conclusions were reached: 1.