Publications by authors named "Komlan Koumbogle"
Article Synopsis
- The study investigates how different punch coatings (Uncoated steel, CrN, ZrN, TiN, and Ultracoat) affect the sticking of microcrystalline cellulose (MCC) during the tableting process with a Manesty F3 press.
- The analysis focused on surface properties like roughness, free energy, and functional groups, revealing that TiN and uncoated steel had the highest adhesion to MCC after pressing.
- Results indicated that surfaces with higher Lewis base components in their surface free energy were more prone to sticking due to stronger interactions with evaporating water, and a high percentage of polar functional groups also contributed to this behavior.
Punch sticking is a recurrent problem during the pharmaceutical tableting process. Powder moisture content plays a key role in the buildup of sticking; it evaporates due to increased tablet temperature, accumulates at the punch-tablet interface, and causes sticking through capillary force. This study investigated the effects of compaction pressure (CP), compaction speed (CS), and lubrication level (magnesium stearate (MgSt) ratio) on tablet surface temperature (TST) and tablet surface moisture content (TSMC).
View Article and Find Full Text PDFThe moisture content of pharmaceutical powder is a key parameter contributing to tablet sticking during the tableting process. This study investigates powder moisture behavior during the compaction phase of the tableting process. Finite element analysis software COMSOL Multiphysics 5.
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