The impact of war on people with type 2 diabetes in Ukraine: a survey study.

Background: Although the number of studies reporting war-induced effects on the health of the Ukrainian population has been growing, there are still little data on assessing patients with type 2 diabetes (T2D) during the war. This study aimed to evaluate the impact of war on T2D patients' health to define key risk factors promoting disease progression.

Methods: A survey covering various aspects of T2D patients' experience and glycemic control data was conducted from June 2022 to February 2024.

Efficacy of combination therapy tadalafil plus tamsulosin in ureteral stents-related symptoms relief.

Introduction: Ureteral stents-related symptoms (USRs) are the common complications of ureteral stenting. Tamsulosin a selective alpha-1 blocker and Tadalafil a PDE-5 inhibitor are one of drugs have been used for USRs relief. In this study we aimed to evaluate the effectiveness and safety of combination therapy Tamsulosin+Tadalafil for treating USRs comparing it with the efficacy of either Tamsulosin or Tadalafil monotherapies.

Probiotic for Pancreatic β-Cell Function in Type 2 Diabetes: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial.

Introduction: Many clinical studies have proved the effectiveness of probiotics in metabolic disorders associated with insulin resistance. However, the impact of probiotic therapy on pancreatic β-cell function is ambiguous. The influence of probiotic supplementation vs.

FAMILIAL NON-MEDULLARY THYROID CARCINOMA.

Background: Familial non-medullary thyroid carcinoma (FNMTC) is defined as cancer developing in two or more first-degree relatives if predisposing factors, for example, radiation, are absent. The disease can be either syndromic, when it is a component of complex genetic syndromes, or non-syndromic (95% cases). The genetic basis of non-syndromic FNMTC is unknown; the clinical behavior of tumorsis unclear and, at times, contradictory.

Vitamin D3 deficiency is associated with more severe insulin resistance and metformin use in patients with type 2 diabetes.

Background: Vitamin D3 (vit. D3) deficiency is considered as one of the main factors involved in the development of type 2 diabetes (T2D). We assessed insulin resistance (IR), β-cell functional activity and metabolic profile according to 25(OH) vit.

Metabolic Benefits of Probiotic Combination with Absorbent Smectite in type 2 Diabetes Patients a Randomised Controlled Trial.

Background: Numerous non-drug therapies have emerged in recent years for the prevention and improvement of type 2 diabetes (T2D). However, therapies based on dietary modification and/or microbiota may replace a large part of drug therapies in the coming years.

Aim: The aim of the current study was to conduct placebo-controlled randomize clinical trial for the efficiency of a combination of multiprobiotics with smectite absorbent gel (Symbiter-Forte formulation) as an adjunction to the standard anti-diabetic therapy.

Beneficial effects of probiotic combination with omega-3 fatty acids in NAFLD: a randomized clinical study.

Background: The manipulation of gut microbiota via administration of probiotics has been proposed as a potential strategy for the treatment of non-alcoholic fatty liver disease (NAFLD). Hence, we performed a double-blind single center randomized placebo-controlled trial (RCT) to evaluate the efficacy of coadministration of probiotics with omega-3 vs. placebo in type-2 diabetic patients with NAFLD.

[Correction by vitamin D3 of disturbed metabolism in patients with diabetes mellitus types 1 and 2].

Vitamin D deficiency is an increasingly recognized public health problem of population as a whole and against a background of different chronic diseases. The aim of the study was to determine the status of D-vitamin, mineral, carbohydrate and lipid metabolism in patients with diabetes 1 and 2 types and in the case of vitamin D3 application. The data on the impact of vitamin D3 deficiency on mineral, carbohydrate and lipid metabolism, as well as on pancreatic beta-cells functional activity in patients with diabetes mellitus types 1 and 2 are presented.

[Mineral metabolism and metabolic markers in patients with concomitant endocrine disorders and vitamin D3 deficiency].

We studied patients with a combination of diabetes and thyroid disorders, was assessed the provision of vitamin D3, markers of insulin resistance, impaired glucose and mineral metabolism. Studies indicate that patients with a marked deficiency of vitamin D3, and decompensation of carbohydrate obmela disturbance of mineral metabolism.

[Correction of atherogenic dyslipidemia with honey, pollen and bee bread in patients with different body mass].

Aim: To assess efficacy of treatment of patients with atherogenic dyslipidemia (ADL) with beekeeping products (honey, pollen, bee bread).

Material And Methods: ADL parameters were examined in 157 patients (64 males and 93 females) aged 39 to 72 (mean age 61,7 + 8,5 years) with ADL. Products of beekeeping were given in the absence of allergy and individual resistance to honey, pollen, bee bread.

[Pharmacokinetic and pharmacodynamic characteristics of antihypertensive drugs in the treatment of hypertensive patients with chronic diseases of the liver].

Aim: To determine optimal treatment of arterial hypertension (AH) in patients with hepatic cirrhosis (HC) basing on pharmacokinetic and pharmacodynamic characteristics of angiotensin-converting enzyme (ACE) inhibitors and beta-adrenoblockers (BAB).

Material And Methods: A total of 360 patients with AH of the second degree, steatosis and alcoholic HC of class A according to Child-Pue participated in the study. The control group consisted of 120 patients with peptic ulcer in remission and normal function of the liver.

Effects of N-acylethanolamines and various antimitotic agents on apoptotic DNA fragmentation in conventionally normal and tumor tissue of human adrenals.

Aim: To study effects of N-acylethanolamines (NAE) and various antimitotic agents: taxol, colchicine, and cytochalasin B on the DNA fragmentation extent in conventionally normal (CNT) and tumor tissue of human adrenal cortex.

Methods: Six types of adrenal tumor tissue of 84 patients were analyzed. Slices of tissue was incubated at 37 degrees C for 3 h in the presence of NAEs and antimitotics, DNA was extracted and analysed in agarose gel.

[Urgent interventions for invasive thyroidal carcinoma].

There was summarized the experience of treatment of the thyroid gland cancer, invading trachea (larynx) and other neighboring structures of the neck in 42 patients, whose state was estimated as severe one and neoplastic process--as nonoperable. Optimal surgical methods were applied depending on clinical signs of thyroidal carcinoma. In 36 patients the palliative resection of thyroid gland (in 6--with tracheostomy addition) was done, in 6--intervention was restricted by tracheostomy formation.

[The application of radiosurgical methods in the treatment complex of Itsenko-Cushing disease].

More then ten year follow up of 154 patients with Itsenko-Cushing disease (ICD) is presented, of whom in 69-one sided and in 89-bilateral transcatheteric transvenous adrenal glands destruction (TTAGD) was done. In 50% of them the remission of disease for a period of 5-10 years was observed.