[Interaction of morphine and non-steroid anti-inflammatory agents].

A study was made of the analgesic action of combined morphine and nonsteroidal anti-inflammatory agents (NAIA)--voltaren, ibuprophen and metindol. It was established that injection of morphine prior to NAIA gives rise to a reduction in the analgesic effect, whereas the combined use of the drugs or administration of NAIA following morphine entails the retention of the effect. Pretreatment with prostaglandin E produces opposite changes in the effect of the analgesics--potentiation of analgesia upon morphine injection and its reduction after NAIA.

[Characteristics of the action of non-narcotic analgesics in diabetics].

Patients with diabetes mellitus were examined for the action of non-narcotic analgesics during oral cavity sanitation. All the drugs under study (amidopyrine, pyranal, baralgin, probon) taken per os increased the threshold of tactile painful sensitivity and the threshold of pain endurance in patients with diabetes mellitus to a greater degree than in normal subjects. No such differences were recorded after diazepam intake under the same conditions.

[Pain-relieving action of voltaren and methindole determined in inflamed tissue].

As measured on an inflamed rat paw, voltaren raised the pain sensitivity threshold 4-5-fold, whereas on a non-inflamed paw, 2-2.5-fold. The effect seen was dose-dependent.

[Effect of enkephalins and morphine on the neurons of the midbrain reticular formation].

It has been established in experiments on conscious cats that variation in spontaneous activity of the midbrain reticular formation neurones in response to microiontophoretic application of morphine largely coincides with the pattern of changes in impulsation in response to administration of leu-enkephalin rather than to met-enkephalin. Concurrent application of the subthreshold dose of enkephalins and morphine has revealed a possibility of the effects summation, the highest pharmacological activity being exhibited by leu-enkephalin combined with morphine. Selective blocking by enkephalins and morphine has been observed of evoked neuronal responses to peripheral exposures (ECS, stimulation of the sciatic nerve).

[Effect of morphine and amidopyrine on the blood serum protein spectrum against a background of steroid hormone administration].

Administration of morphine and amidopyrin in experimental hypercorticism (hydrocortisone and DOCSA excess) results in the increased content of albumins and the decreased level of globulins. On the whole, the pattern of action of the steroid hormones on the protein spectrum of blood remains unchanged even after administration of analgesic agents.

[Influence of morphine and reserpine on the experimental effect of electrostimulation of biologically active points].

In experiments on unanesthetized cats, electric stimulation of biologically active points (BAP) led to a prolonged facilitation of the amplitude of brain cortex evoked potentials. Morphine (2--2.5 mg/kg) produced unidirectional changes (with respect to electric stimulation) in the electrophysiological indices.

[Action of morphine and fentanyl during the electrostimulation of biologically active points].

Experiments on rabbits showed the summation of analgesia induced by electric stimulation of biologically active points (BAP) and by administration of morphine and fentanil within a certain dosage range. The differences recorded in cortical evoked potentials in response to excitation of BAP and of an active point of the rabbit forefoot were levelled off in the presence of morphine administration.

[Morphine and promedol interaction with the plasma proteins of allergized rabbits].

It has been established that morphine interacts with albumins, alpha 2- and beta-globulins, while promedol with all globulin fractions and to a less measure with plasma albumins of the intact rabbit. Interaction of morphine and especially that of promedol with the same protein fractions of allergizated animals proceeds more actively and is characterized by a more pronounced formation of biological complexes with alpha 1-globulins. Decreased pharmacological activity of morphine and promedol coincides with intensification of their interaction with proteins.

[Action of morphine and amidopyrine against a background of mineralocorticoid hormone and its antagonist].

The effect of morphine and amidopyrine, used against the background of a mineralocorticoid hormone or its antagonist excess (multiple administration of desoxycorticosteron acetate or verospiron), is mitigated. The pain-allaying effect of analgesics and their influence on the behavioral reactions are less marked in both models than it is in intact animals and their toxocity is down.

[The effect of non-steroid antiphlogistic drugs on the number of antibody-forming cells during the primary immune response].

In mice immunized with sheep erythrocytes introduction of acetylsalycilic acid (250 mg/kg), sodium salicylate (100 mg/kg) and mephenamic acid (100 mg/kg) exerted an inhibitory effect on the synthesis of antibody-forming cells and the titre of hemagglutinines in immunized animals. The acetylsalicylic acid and sodium salicylate are more effective on the 3--5th post-immunization day; the maximal effect of the mephenamic acid becomes apparent on the 7th day and its action is more lasting.

[Effect of thyrocalcitonin on the pain sensitivity in animals].

With a single parenteral introduction of thyrocalcitonin (TCT) the algesthesia of soft tissues (tall skin, paw) is moderately increasing, while the algesic action of morphine and promedol against the background of TCT-gets weaker. And contrarywise algesthesia of hard tissues of the tooth becomes significantly lower under the effect of TCT and this continues for a long time.

[A neurophysiologic analysis of the effect of amidopyrine at the thalamo-cortical level of the somatosensory system].

Acute experiments were conducted on nonanesthetized cats; it was shown that amidopyrin (10, 20 mg/kg, intravenously) decreased the level of the background activity of the thalamic neurons, and, at the same time, increased the amplitude of the focal primary bioelectrical reactions. It is supposed that amidopyrin synchronized evoked reactions of the cells in the thalamus, as well as in the cortex. On the other hand, amidopyrin diminished the excitability of the cortical neurons participating in the interzonal connections.

[Study of the pharmacodynamics of morphine and aminopyrine under conditions of alloxan diabetes].

The effects of morphine and amidopyrine were studied in tests on albino rats with experimental alloxan diabetes. Investigations showed the analgesic effects of morphine and the pupillary reflex following administration of this drug to subside, its toxicity remaining stationary. The anodyne action of amidopyrine and its toxicity grow in intensity.

[Effect of aminazine on the lymphocyte blast transformation].

Chlorpromazine used in low concentrations during in vivo experiments stimulates the lymphocytes blast transformation reaction (LBR) in the blood of donors and in that of rabbits, while in large doses it suppresses this reaction. When LBR is stimulated with phitohemagglutinin (PHA), chlorpromazine weakens the reaction. Follwing a single intravenous injection of chlorpromazine to a rabbit the spontaneous LBR rises, while the stimulating effect of PHA declines.

[Mechanism of the action aminopyrine].

In acute experiments on unanesthetized cats with a single and paired stimulation the effect of aminopyrine (5-30 mg/kg, intravenously) on bioelectric reactions in the conduction system of afferent impulsation at the thalamo-cortical level was studied. Aminopyrine is shown to highten the amplitude of an evoked potential of the somato-sensory cortex and of the specific transmitting nucleus of the thalamus upon stimulation of the radial nerve and to significantly lengthen with paired stimulation the regeneration period of the neuronic systems excitability in the structures under review. Investigations into the states of the cortical neuronic systems proper showed aminopyrine capable of increasing the number of high-frequency oscillations and the amplitude of the interzonal response as well as to lengthen with paired stimulation the restoration period of the neuronic systems excitability.