[Gross anatomical study of veins in the orbit].

The aim of this study is to clarify the major route of venous return in the orbit. Minute dissections were performed in 10 adult cadavers (5 males and 5 females) after being fixed in a 10% formalin solution. The superior ophthalmic vein (SOV) and its ascending anastomotic branch were consistently well-developed (the average maximum diameter: 6.

[Radiation therapy for unresected gastric lymphoma].

Six consecutive patients with unresected gastric lymphoma which were treated by radiation therapy between November, 1976 and March 1989 were reviewed. Radiation therapy was performed using involved fields, total radiation dosages of which ranged from 25.2 to 36 Gy (mean, 29.

[The role of gallium-67 citrate scintigraphy in gastro-intestinal malignant lymphoma].

To evaluate the clinical usefulness of gallium-67 scintigraphy in the detection of the gastrointestinal (GI) non-Hodgkin's lymphoma (NHL) and in the assessment of the therapeutic effects, gallium-67 scintigraphy was reviewed on 24 cases (25 lesions; stomach in 20, ileum in 2, and terminal ileum and/or cecum in 3). Twenty-three out of the 25 lesions (92.0%) were detected by gallium-67 scintigraphy, while barium study could detect all of the 25 lesions.

Mutational and gene dosage analysis of calcium-activated potassium channels in Drosophila: correlation of micro- and macroscopic currents.

In Drosophila, two Ca2(+)-activated K+ currents, ICF and ICS, have previously been distinguished in conventional voltage clamp experiments. The slowpoke (slo) mutation eliminates ICF specifically. We report that in patch clamp recordings a single-channel Ca2(+)-activated K+ current is readily distinguished from other channel activities in normal larval muscle membrane, whereas no such current is observed in slo muscles.

Age-related changes in cerebral white matter measured by computed cranial tomography.

Changes in the cerebral white matter in relation to aging were studied quantitatively by computed cranial tomography (CT) in 70 healthy subjects aged 30 to 94 years. There were no age-related changes in the CT number of the white matter (WMCT) in 41 younger subjects aged 30 to 65 years. But, there was a significant negative correlation between age and the WMCT in 29 elderly subjects aged 66 to 94 years.

The role of gallium 67 imaging in non-Hodgkin's lymphoma of the gastrointestinal tract.

To evaluate the clinical usefulness of gallium 67 imaging in the detection of gastrointestinal (GI) non-Hodgkin's lymphoma (NHL) and in the assessment of the therapeutic effects, images were reviewed in 24 cases (25 lesions: stomach, 20; ileum, 2; and terminal ileum and or cecum, 3) and were compared using barium studies and, in 16 cases, computerized tomography (CT). In all, 23 (92.0%) of the 25 lesions were detected by 67Ga citrate imaging, the barium studies detected all 25, and CT detected 15 of 16 lesions (93.

[Radiation-induced esophageal stricture in patients with non-small cell lung cancer treated with chemoradiotherapy].

Five out of 165 cases (3.0%) which were treated for non-small cell lung cancer with radiotherapy (98 cases were treated with chemoradiotherapy, and the other 67 cases, radiotherapy alone) developed esophageal stricture. Their clinical courses, the relationship among radiation dosage, combination with chemotherapy, the length of the irradiated esophagus, and the occurrence of esophageal stricture were reviewed.

Central respiratory oscillator: phase-response analysis.

To investigate properties of the central respiratory oscillator, phrenic nerve activity, perturbed by electrical stimulation of the middle external intercostal nerve, was analyzed in rabbit by using a phase-response curve (PRC). During inspiration, the stimuli (4-8 pulses) caused all-or-none responses, i.e.

Application of lipid microsphere drug delivery system to steroidal ophthalmic preparation.

The applicability of a lipid microsphere drug delivery system to ophthalmic preparations was examined using a lipid microsphere containing hydrocortisone 17-butyrate 21-propionate (HBP). 3H-labelled HBP ophthalmic suspension and 3H-labelled HBP lipid microsphere were applied to rabbit eyes, and the eyes were enucleated after 1 and 3 hours to determine 3H-labelled HBP levels in the ocular tissues. The lipid microsphere proved to deliver the drug to the anterior ocular tissues more significantly than the ophthalmic suspension.

Application of a drug delivery system to a steroidal ophthalmic preparation with lipid microspheres.

The applicability of a drug delivery system to an ophthalmic preparation was examined using lipid microspheres containing hydrocortisone 17-butyrate 21-propionate (HBP). A 3H-labelled HBP ophthalmic suspension and 3H-labelled HBP lipid microspheres were applied to rabbit eyes, which were then enucleated at fixed intervals to determine the level of 3H-labelled HBP in ocular tissues. The lipid microspheres were shown to deliver the drug to the anterior ocular tissues more effectively than the ophthalmic suspension.

Normal pressure hydrocephalus. Neuropathological study.

The pathological changes in the brains of seven patients who had been clinically diagnosed as normal pressure hydrocephalus (NPH) are described and the possible etiological mechanisms are discussed. The pathological findings in all cases consisted of demyelination akin to Binswanger's type of encephalopathy, especially in the frontal lobes. Arteriosclerosis accompanied by occasional organized thrombi and scattered microinfarcts in the periventricular white matter were seen.

Amplification of N-myc in a rhabdomyosarcoma.

N-myc is a member of the myc oncogene family and has been thought to be specific to neurogenic cells, since it is amplified in some neuroblastomas, retinoblastomas and small-cell lung carcinomas with endocrine properties. Hybridization analyses of DNAs isolated from surgically removed tumors revealed that N-myc was amplified about 6-fold in one of the three embryonic rhabdomyosarcomas examined. The rhabdomyosarcoma containing the amplified N-myc had metastasized into bone marrow, which is preferentially involved in the metastasis of neuroblastomas but is usually not involved in the case of rhabdomyosarcomas.