Publications by authors named "Komathi Perumal"
Human epidermal growth factor receptor 2 (HER2) is known for its oncogenic activities in diverse cancers, including non-small cell lung cancer (NSCLC). However, the prevalence of alterations in Malaysian NSCLC patients remains unreported. This study examined the prevalence and characteristics of mutations and amplification in a Malaysian cohort.
View Article and Find Full Text PDFRenal cell carcinoma (RCC) is the most lethal genitourinary malignancy. Obesity is a risk factor for RCC development. The role of adipokines in the relationship between obesity and RCC requires confirmatory evidence in the form of a systematic review and meta-analysis, specifically for visfatin, omentin-1, nesfatin-1 and apelin.
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- The study aimed to explore the role of leptin and leptin receptor expressions in clear cell renal cell carcinomas (ccRCC) among obese and non-obese patients, using immunohistochemistry (IHC) for assessment.
- Despite investigating 60 patients, the results showed no significant differences in leptin and leptin receptor levels between cancerous and adjacent non-cancerous kidney tissues, nor between obese and non-obese patients with ccRCC.
- This suggests that leptin and its receptor might not be key biomarkers for ccRCC prognosis or pathology in the context of obesity, challenging assumptions about their role in cancer linkages.
Renal cell carcinoma (RCC) is the commonest from of renal neoplasm. Although surgery is a successful curative treatment for localized RCC, most patients are diagnosed with advanced or metastatic RCC, which has poor prognosis. RCC is classified by stage and grade using tissue samples.
View Article and Find Full Text PDFObesity is a recognized risk factor for renal cell carcinoma (RCC) the commonest form of kidney cancer. Both obesity and RCC are serious diseases with increasing incidence yearly. This review examined certain obesity associated measurements and adipokines as detection/prognostic indicators for RCC.
View Article and Find Full Text PDF: Metabolic imbalance in renal cell carcinoma (RCC) can lead to abnormal adiponectin levels. : To evaluate circulating adiponectin as a detection or predictive marker for RCC. : A comprehensive literature search and meta-analysis was performed on studies reporting circulating adiponectin levels and RCC.
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