Publications by authors named "Komang Agus Rai Ardika"

Doxycycline hyclate (DOXY) is a tetracycline derivative known as the broad-spectrum bacteriostatic drug. DOXY has been suggested as the first-line antibiotic for diabetic foot ulcers (DFU). Unfortunately, the long-term availability of DOXY in both oral and conventional topical dosage forms reduces its therapeutic effectiveness, which is closely linked to gastrointestinal side effects and acute pain during therapy, as well as uncontrolled DOXY release at the wound site.

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Article Synopsis
  • - Cabotegravir (CAB) is an antiretroviral therapy for HIV that faces challenges in oral and injection forms due to low solubility and administration difficulties, making the development of a new delivery system crucial.
  • - A vaginal drug delivery system for CAB was created using thermosensitive and mucoadhesive gel formulations, which improve drug distribution and bioavailability within the vaginal mucosa.
  • - The study validated a UV-visible spectrophotometry method to accurately quantify CAB in various matrices, confirming the gel preparations maintain uniform drug content and a controlled release over 24 hours, but further methods are needed for in vivo studies.
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As an effective anti-HIV drug, cabotegravir (CAB) is currently administered via oral and injection routes, leading to several drawbacks, such as poor oral bioavailability and problems in the injection application process, as well as low drug concentration in vaginal tissue of woman patients. To overcome these issues, for the first time, we formulated CAB into three types of vaginal gels, considering the benefits of vaginal tissue as a delivery route. Thermosensitive gel, mucoadhesive gel, and the combination of these gels were developed as suitable carriers for CAB.

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