Publications by authors named "Komal S Keerthy"
Brown adipose tissue (BAT) is a specialized metabolic organ responsible for non-shivering thermogenesis. Recently, its activity has been shown to be critical in systemic metabolic health through its utilization and consumption of macronutrients. In the face of energetically demanding states, metabolic flexibility and systemic coordination of nutrient partitioning is requisite for health and survival.
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- - Skeletal muscle significantly impacts overall metabolic health, particularly in glucose use and insulin sensitivity, but its role in regulating fat metabolism is less understood.
- - Research on mice showed that when the gene Krüppel-like factor 15 (KLF15) is deleted specifically in skeletal muscle, it leads to issues like less effective fat uptake and increased levels of fats in the bloodstream, which contribute to insulin resistance and fat buildup in organs.
- - Interestingly, feeding the mice a diet high in short-chain fatty acids helped to alleviate some of these metabolic problems, highlighting the importance of skeletal muscle in managing fat metabolism and overall metabolic health.
Substantial evidence implicates crosstalk between metabolic tissues and the immune system in the inception and progression of obesity. However, molecular regulators that orchestrate metaflammation both centrally and peripherally remains incompletely understood. Here, we identify myeloid Krüppel-like factor 2 (KLF2) as an essential regulator of obesity and its sequelae.
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