Chromium is an essential element in various industrial processes, including stainless steel production, electroplating, metal finishing, leather tanning, photography, and textile manufacturing. However, it is also a well-documented contaminant of aquatic systems and agricultural land, posing significant economic and health challenges. The hexavalent form of chromium [Cr(VI)] is particularly toxic and carcinogenic, linked to severe health issues such as cancer, kidney disorders, liver failure, and environmental biomagnification.
View Article and Find Full Text PDFGenus Bauhinia has been widely used in the treatment of diabetes, malaria, cough, headache, fever, piles, dysentery, flatulence, diarrhoea, ulcer and cardiovascular problems. Among 600 species of this genus, Bauhinia variegata, B. purpurea, B.
View Article and Find Full Text PDFThe diversified eating habits and religious culture of Indian population may be one of the reasons they largely contribute to the global diabetes burden. In the present investigation, an approach was carried out to explore hub genes in the Indian population with Type 2 Diabetes Mellitus (T2DM) that are scantily reported in the GWAS catalogue and probable potential anti-diabetic drugs from plants. This computational approach unwrapped LEP (leptin) as the hub gene among 170 genes analyzed with 14 non-synonymous single nucleotide polymorphisms (nsSNPs) with MAF < 0.
View Article and Find Full Text PDFUnlabelled: Lichens are used in folklore medicines across the globe for wound healing and to treat skin disorders and respiratory diseases. They are an intricate symbiosis between fungi and algae with the domination of fungal counterparts. Recent research studies pointed out that yeast is a third major partner in lichens.
View Article and Find Full Text PDFFungi are known to produce diverse scaffolds possessing unique biological activities, however, to date, no molecule discovered from a fungal source has reached the market as an anti-cancer drug. Every year number of cytotoxic molecules of fungal origin are getting published and critical analysis of those compounds is necessary to identify the potent ones. A review mentioning the best cytotoxic fungal metabolites and their status in the drug development was published in 2014.
View Article and Find Full Text PDFPhotocatalytic treatment of wastewater using nanomaterials is an efficient energy saving technology. Yet the practical application of the technology is limited because of difficulty in developing the stable, supported photocatalytic nanoparticles that can be used under continuous flow conditions. Here, we report an efficient removal of glyphosate (GLP) and Cr(VI) from water under batch as well as continuous flow conditions using the activated carbon fiber (ACF)-supported nanocomposite of CoNiWO (CNW) and g-CN (gCN), as a photocatalyst.
View Article and Find Full Text PDFScanning Spreading Resistance Microscopy is a well-established technique for obtaining quantitative two- and three-dimensional carrier profiles in semiconductor devices with sub-nm spatial resolution. However, for sub-100 nm devices, the use of focused ion beam becomes inevitable for exposing the region of interest on a sample cross section. In this work, we investigate the impact of the focused ion beam milling on spreading resistance analysis and we show that the electrical effect of the focused ion beam extends far beyond the amorphous region and depends on the dopant concentration, ion beam energy, impact angle, and current density.
View Article and Find Full Text PDFDeveloping drug formulations for poorly water-soluble drugs is a major challenge for pharmaceutical industries as the poor water solubility limits bioavailability of these drugs. Production of nanoparticles/microparticles of these drugs is one of the ways to improve dissolution rates by increasing interfacial area for dissolution. Curcumin, a compound obtained from the rhizome of curcuma longa (turmeric roots), is a pharmaceutically viable molecule.
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