Association of the Genotype of TNFα with the Efficiency of the Intensive Phase of Chemotherapy and Formation of the Sizes of Destruction Cavities in Patients with Pulmonary Tuberculosis.

The interrelation between the TNFα gene polymorphism and the effectiveness of the intensive phase of chemotherapy in patients with pulmonary tuberculosis, as well as the formation of diameter of the sizes of destruction cavities was studied. It was revealed that the most adverse course of the disease and a high frequency of formation of destruction cavities are associated with the GG genotype of the TNFα gene.

Photovoltaic effect in methylammonium lead triiodide single crystal.

Due to the crystalline acentricity leading to the bulk photovoltaic effect (PV) the ferroelectrics (FEs) are considered as important candidates for creation of the PV cells overcoming the Shockley-Queisser limit of semiconductors. However, this research direction still requires more investigations to develop reliable pathways for PV efficiency optimization. The recent progress in the power conversion efficiency of the cells based on the organic-based compounds such as CHNHPbIperovskite attracted much attention of the scientists.

Growth, structure, and temperature dependent emission processes in emerging metal hexachloride scintillators CsHfCl and CsZrCl.

Crystals of metal hexachlorides CsMCl (M = Hf or Zr) have recently emerged as promising materials for scintillation applications due to their excellent energy resolution. In this work, we investigated the crystal structure and scintillation properties of CsHfCl and CsZrCl crystals in the broad temperature range from 9 to 300 K. X-ray diffraction data confirmed the same cubic structure (space group ) for CsHfCl and CsZrCl over the entire examined temperature range.

Psychological Continuum of Elderly Patients Suffering from Arterial Hypertension with Metabolic Syndrome, Against the Background of Chronotherapy with a Fixed Combination of Amlodipine, Lisinopril and Rosuvastatin.

Aim        To study the psychological continuum in elderly patients with arterial hypertension associated with metabolic syndrome during the chronotherapy with a fixed combination (FC) of amlodipine, lisinopril, and rosuvastatin.Material and methods        In the inpatient conditions, 63 patients aged 60-74 years with arterial hypertension associated with metabolic syndrome were treated with chronotherapy with a FC of amlodipine, lisinopril, and rosuvastatin (5 / 10 / 10 mg/day in the evening). These patients composed the main group.

[The effect of antihypertensive chronotherapy on indicators of the daily blood pressure profile in elderly patients with arterial hypertension with a history of myocardial infarction.].

Traditional treatment regimens for patients with hypertension are not always effective and need to be improved based on the principles of chronobiology. The purpose of this work is to analyze the effect of preventive chronotherapy with amlodipine, lisinopril, and rosuvastatin on daily blood pressure monitoring. In 62 patients with a history of myocardial infarction and hypertension at the age of 60-74, a fixed combination of amlodipine, lisinopril and rosuvastatin at a dose of 5/10/10 mg 2 hours before reaching maximum systolic blood pressure (preventive chronotherapy), in 63 patients with similar diseases and age, this drug is taken at a dose of 5/10/10mg in the evening, and in 58 people - in the morning (traditional treatment).

Using nominal group technique among clinical providers to identify barriers and prioritize solutions to scaling up opioid agonist therapies in Ukraine.

Background: Opioid agonist therapies (OAT) like methadone and buprenorphine maintenance treatment remain markedly under-scaled in Ukraine despite adequate funding. Clinicians and administrators were assembled as part of an implementation science strategy to scale-up OAT using the Network for Improvement of Addiction Treatment (NIATx) approach.

Methods: Nominal Group Technique (NGT), a key ingredient of the NIATx toolkit, was directed by three trained coaches within a learning collaborative of 18 OAT clinicians and administrators to identify barriers to increase OAT capacity at the regional "oblast" level, develop solutions, and prioritize local change projects.

[Therapy and Rehabilitation of Patients with Pulmonary Tuberculosis and Different Treatment Adherence].

The pulmonary tuberculosis process as dependent on the disease form and the therapy efficacy with the use of Cycloferon in the treatment scheme were investigated. The study had two stages. At the first stage the data concerning 358 patients with primary pulmonary tuberculosis and infiltration (93 patients) or degradation (89 patients) and 176 patients with pulmonary fibrocavernous tuberculosis were analysed.

[Immunomodulator Intensification of Etioropic Therapy in Patients with Advanced Pulmonary Tuberculosis].

The study was aimed at possible increase of the therapy efficacy in patients with advanced tuberculosis by including immunomodulators to the treatment schemes. The data concerning 6034 patients with advanced tuberculosis, mainly fibrocavernous tuberculosis of the lungs, were analysed. Four groups of the patients were randomized.

[Effectiveness of immunomodulating therapy of pulmonary tuberculosis with cycloferon].

Cycloferon was used to treat newly diagnosed, recurrent and long-standing pulmonary TB. The dose of 7,5 g combined with antibacterial therapy caused no complications. The effectiveness of this therapy based on the generally-accepted criteria was significantly higher than standard treatment but varied depending on the character of pathological process.

[Topical aspects of organization of tuberculosis monitoring at the level of a subject of the Russian Federation (in case of the Belgorod Region)].

The paper shows how a tuberculosis monitoring system is under development at the level of the Russian Federation subject--the Belgorod Region. The tuberculosis monitoring system allows an effective control of both tuberculosis-controlling measures determined by the existing normative documents and orders and supplementary measures to enhance the effectiveness of tuberculosis control in the region. Tuberculosis monitoring should be further improved at the regional region by the sections: outpatient visit, antiepidemic measures in the foci; children's sanatorium work, cohorts to be examined by a physio pediatrician.

[Immunological correction in progressive pulmonary tuberculosis].

The authors used their immunological correction method to treat 154 patients with progressive pulmonary tuberculosis. Of them, 38 patients received standard antituberculosis therapy (Group 1), 39 had additionally paravasal lymphotrophic immunological correction (Group 2), and 38 took antituberculous drugs in accordance with individual regimens (Group 3), and 39 patients were treated by individual regimens during immunological correction (Group 4). After termination of the basic course of chemotherapy, clinical cure was achieved in 61.

[Penitentiary tuberculosis as an object of simulative manifestations].

The paper presents the results of a 5-year follow-up of simulative manifestations of tuberculosis at penitentiaries. The high rate of use of penitentiaries as an object of these manifestations has been established, predominantly relapse aggravation of process activity being observed when treatment is continued. The causes of simulative manifestations are diverse; along with a qualitative physical examination, they should be borne in mind by a phthisiatrician in order to make a timely diagnosis.

[The scope and efficiency of inpatient tuberculosis treatment].

There is evidence for the necessity of reorganizing the indications and volumes of antituberculosis care in the tuberculosis hospitals, as shown by the example of one of the subjects of the Russian Federation. The optimum variant of this reorganization lies in the formula of reduction-consolidation-profiling-efficiency by the quality criteria and, when the regional features are kept in mind, is attainable and its alternative is currently absent.

[Limited epidemic of tuberculosis among young socially dysadapted individuals].

Two epidemic outbreaks of tuberculosis were observed among young socially dysadapted individuals at a juvie. They were liquidated, by chiefly implementing social preventive measures and by introducing new chemotherapy regimens.

[Need for correction of the normative-legal base for implementation of a federal program and programs of the subjects of the Russian Federation for Tuberculosis Prevention under the conditions of expected stabilization of the epidemic situation].

Evidence is provided for that there is a need for making additions and amendments in Federal Law No. 77 "On Prevention of the Prevalence of Tuberculosis in the Russian Federation". Amendments are aimed at improving the legal base to increase the financing of governmental programs, at organizing the prevention and treatment of tuberculosis, at optimizing labor in specialized health care services.

[Using non-invasive mask lung ventilation in cardiosurgical patients with acute respiratory distress syndrome].

Twenty patients aged 33 to 71 (54 +/- 6) years (male - 13, female - 7) operated on the heart and main vessels were included in the case study. I.e.

[Postoperative period in early activated patients after myocardial revascularization].

The specific features of an early postoperative period were studied in 115 patients undergone myocardial revascularization who were divided into 3 groups according to the time of postoperative activation. Group 1 comprised 35 patients in whom tracheal extubation was made in the operating room 30-60 min after the end of the operation. Group 2 included 32 patients extubated 2-8 hours after admission to the resuscitation and intensive care unit (RICU); Group 3 consisted of 48 patients undergone tracheal intubation for more than 8 hours.

[Prospects in the search for new biological agents to prevent tuberculosis].

Six biological specimens, including BCG obtained from Mycobacterium tuberculosis or animal tissues in accordance with an original procedure were studied. Their protective efficiency in tuberculosis infection was evaluated by the magnitude of allergic reactions and by pathological tissue changes 5 months after animal immunization and infection. The drug PKP-3 was found to be most effective and its further study is promising.

[Urinary potassium excretion in chronic heart failure].

Mechanisms were studied of urinary potassium excertion in patients with chronic heart failure (CHF). A total of 78 patients were examined presenting with functional class I-IV CHF.

[Treatment of mild and moderate hypertension with enalapril (multicenter study of enap and enap N in Ukraine)].

Aim: Assessment of efficiency and safety of enalapril (enap) and its combination with hydrochlorotiaside (enap-N).

Materials And Methods: 127 patients with mild and moderate blood hypertension entered an open non-comparative multicenter trial. 60 of them received enap (group 1), 67--enap N (group 2).

[Cardio-cerebral hemodynamics and the prostanoid system in patients with the initial stages of essential hypertension].

There is an interrelationship between the central and cerebral hemodynamics in those young adults who are in the incipient stages of their essential hypertension. Prostanoids have their part in formation of types of central hemodynamics and origination of its integration with cerebral bloodflow during the course of the illness.