Psilocin and ketamine microdosing: effects of subchronic intermittent microdoses in the elevated plus-maze in male Wistar rats.

Short-term moderate doses of serotonergic and dissociative hallucinogens can be useful in the treatment of anxiety. Recently, a trend has developed for long-term intermittent 'microdosing' (usually one-tenth of a 'full' active dose), with reports of long-lasting relief from anxiety and related disorders; however, there is no scientific evidence for the efficacy of therapeutic microdosing nor to show its lasting effects. The objective of this study was to test for lasting effects on anxiety in rats after microdosing with ketamine or psilocin.

[18-year survival in a case of repeated excision of malignant conjunctival melanoma].

The case of 18 years survival with repeatedly excised conjunctival malignant melanoma is described. The survival period is extraordinary long in that case. However, the case is illustrative for some general characteristics of conjunctival melanoma, particularly in a comparison with cutaneous melanomas.

[Decentration of posterior chamber intraocular lenses].

In a group of 300 patients with a posterior chamber lens in 19% its decentration was found, in 2.3% the iris capture syndrome. The author discusses possible causes of decentration of the implanted lens, possibilities of its therapy.

[Inflammatory intraocular complications after placement of retropupillary lenses].

In 194 patients aged 32-81 years 200 retropupillary lenses were administered. 129 lenses were implanted into the sulcus ciliaris, 71 lenses into the lenticular capsule. The surgical technique was the same in both groups.

Periosteal Ewing's sarcoma.

Periosteal Ewing's sarcoma is an uncommon, but well documented origin of this malignant condition with radiographic signs, different from intramedullary growing tumours. Imaging modalities like CT or MRI supply proof of macroscopically intact endosteal cortical surface and free medullary cavity in long bones affected by this periosteal type of malignancy. Definite confirmation is valid after a careful microscopic investigation of the resected specimen.

[Spinal stenosis].

Space conditions in the spine canal play the decisive role in the origin of neurological difficulties connected with pressure on the spinal cord and its radices. For the diagnosis of spinal stenosis the dimensions of the spine canal are of importance: sagital, interpedicular, interarticular and the width of lateral recessus of the spine canal. The diagnostics of spinal stenosis is based on the anterior-posterior and lateral picture of the spine, CT examination and contrast examination of the spine canal--myeloradiculography.

[Extramedullary Ewing's sarcoma].

The authors refer to six observations of periostal Ewing's sarcoma and describe its X-ray symptomatology. It differs considerably from the commonly known picture of centrally, intramedullar-originated Ewing sarcomas and tumours, diagnosed at considerable advanced stage. The possibility of periosteal origin of Ewing's sarcoma must be considered in differential diagnosis of periostoses and the patients must be examined in a complex way, particularly by computer tomography (and in the future also by MR tomography) in order to demonstrate that the medullar space of the bone is not affected by the tumour.

"Slimy eyes phenomenon" in mice intraperitoneally injected with Pseudomonas aeruginosa cells or cell products.

Mice intraperitoneally treated with various Pseudomonas aeruginosa products or lipopolysaccharides of some selected Enterobacteriaceae representatives were found also to react by an increased slime secretion of the eye conjunctivae. The condition, tentatively designated as "Slimy Eyes Phenomenon", started to develop shortly post-treatment, culminated within 24-48 h when the eyes became fully glued up with slime, and receded 48-72 h later, leaving no sequelae for the eye or the general condition of the animal. No such phenomenon has to date been observed in other laboratory animal species.

Retinal pigment epithelium dystrophy in central serous detachment of sensory epithelium.

The incidence of central serous neuro-epithelial detachment in the polulation living in the health district Prague-10 was found to be one in 22,000 inhabitants a year. The cases were classified into three types: A. Inkblot diffusion 60%; B.