The Effects of Bioactive Compounds on PTSD Treatment.

Post-traumatic Stress Disorder (PTSD) is a psychiatric disease that arises in individuals who have experienced a traumatic event such as combat exposure, childhood physical abuse, sexual violence, physical assault, an accident, etc. Being difficult to diagnose and treat, PTSD is actively studied in areas of medicine, psychiatry, biochemistry, and rehabilitation. PTSD is characterized by significant comorbidity and is accompanied by depression and anxiety.

Features of apoptotic and proliferative processes in experimental infected radiation-induced skin ulcer under conditions of photodynamic therapy and the use of platelet-rich plasma.

Objective: . Aim: The purpose of the study was to identify the features of apoptotic and proliferative processes in experimental Staphylococcus aureus-infected radiation skin ulcer under conditions of photodynamic therapy and the use of platelet-rich plasma.

Patients And Methods: Materials and Methods: An experimental study was conducted on 95 six-month-old male rats of the WAG population, which were divided into three groups.

Effect of β-amyloid peptide 42 on the dynamics of expression and formation of Аβ40, IL -1β, TNF α, IL -6, IL -10 by peripheral blood mononuclear cells in vitro and its correction by curcumin.

The toxic effect of Аβ-oligomers accompanies chronic inflammation, with cytokines as main mediators. Therefore, the cytokine link of inflammation becomes a new target on the way to restrain amyloidosis. The aim of the study was the effect of aggregated Аβ42 on the dynamics of expression and formation of endogenous Аβ40 and cytokines (IL-1β, TNFα, IL-6, IL-10) by peripheral blood mononuclear cells in vitro and its correction by curcumin.

TP53 codon 72 polymorphic variants (Rs1042522) frequency in the Ukrainian population.

Objective: To estimate frequencies of polymorphic variants of TP53 codon 72 in the Ukrainian population.

Materials And Methods: We determined the allele frequencies for 148 healthy people. Genotyping was performed by allele specific polymerase chain reaction.

Aberrant expression of selenium-containing glutathione peroxidases in clear cell renal cell carcinomas.

Aim: To find putative diagnostic markers for clear cell renal cell carcinomas (ccRCC).

Material And Methods: Quantitative polymerase chain reaction (Q-PCR), bisulfite treatment, methylation-specific PCR, analysis on cBioPortal for Cancer Genomics.

Results: We have found that expression of GPX1, GPX3, and GPX4 genes was decreased in ccRCC.

[Pathogenesis of the lethal postoperative cerebral inflammatory-purulent complications in neurooncological patients].

The main and immediate causes of death, pathogenetic mechanisms of postoperative cerebral inflammatory-purulent complications (CIPC) in patients, suffering the brain tumour, were analyzed. The main pathogenetic patterns of the postoperative period course in the CIPC occurrence were studied, basing on the data of analysis of 30 patients, who died after the operation. There was proved, that the sepsis occurrence on the background of postoperative meningoencephalitis means the lethal ending of the disease.