The role of the greater trochanter pain syndrome in lumbar degenerative disc disease surgery.

Purpose: Greater trochanter pain syndrome (GTPS) is highly discussed during spine surgeons, accompanies lumbar pain and complicates differential diagnosis. The aim is to raise awareness among physicians and demonstrate the lumbar spine degenerative diseases (LSDD) association with GTPS.

Methods: A retro-prospective analysis enrolled 172 patients with LSDD with GTPS signs.

Biodegradable Hydrogels Based on Chitosan and Pectin for Cisplatin Delivery.

Preparation of stable hydrogels using physically (electrostatically) interacting charge-complementary polyelectrolyte chains seems to be more attractive from a practical point of view than the use of organic crosslinking agents. In this work natural polyelectrolytes-chitosan and pectin-were used, due to their biocompatibility and biodegradability. The biodegradability of hydrogels is confirmed by experiments with hyaluronidase as an enzyme.

Hydrogels on the Base of Modified Chitosan and Hyaluronic Acid Mix as Polymer Matrices for Cytostatics Delivery.

The development of biodegradable polysaccharide hydrogel matrices for cytostatic delivery can improve the therapeutic results of patients by prolonging the action of the drug, reducing its toxicity and providing additional biological activity by polysaccharides. In this work, N-succinyl chitosan/hyaluronic acid dialdehyde/cytostatic formulations have been prepared using two different chitosan grades (30 kDa and 150 kDa) and hyaluronic acid dialdehyde. The interaction of amino groups of N-succinyl chitosan and aldehydes of hyaluronic acid resulted in the formation of azomethine bonds and was demonstrated using C NMR.

Endothelin-1 and nitrogen oxide metabolites in risk diagnostics of arterial hypertension in persons of young and middle ages occupied in harmful working conditions.

Hypertension is a global public health problem. One of the reasons contributing to the development of arterial hypertension is endothelial dysfunction, which is expressed in the imbalance of vasoactive indicators of vascular tone - nitrogen oxide and endothelin-1. Monitoring the indicators of endothelial dysfunction in workers exposed to harmful occupational factors will help to identify a risk group for the development of occupationally caused diseases of the cardiovascular system and, in particular, arterial hypertension, for early implementation of preventive measures.

New data on the internal organs of a frozen Yukagir bison mummy (Bison priscus Bojanus, 1827), Yakutia, Russia.

The paper presents the first morphological description of the internal organs of a frozen corpse of the steppe bison Bison priscus (Bojanus, 1827) from the Holocene of northern Yakutia. Necropsy revealed that most of the internal organs, including the brain, heart with the main vessels, and reproductive system were well preserved. It demonstrated that the anatomy of this bison was close to that of the genera Bos and Bison.

[THE PROTEOME OF SALIVA AND ITS DIAGNOSTIC POSSIBILITIES].

By the present time, a number of articles has been published testifying an extremely high potential of proteome of saliva for diagnostic of many diseases. At the same time, the conclusions can be made from these publications. In particular, to the effect that studies of proteome of saliva are at the stage of data accumulation only.

[The proteomic profiling of blood serum of children with gastroesophageal reflux disease].

The mass-spectra of proteome of blood serum from healthy children and children with gastroesophageal reflux disease were received. The technology platform including direct proteome mass-spectrometer profiling after pre-fractional rectification using magnetic particles MB WCX was applied. The significant differences in mass-spectra were established manifesting in detection of more mass-spectrometer peaks and higher indicators of their intensity and area in group of healthy children.

The significance of increased levels of end nitric oxide metabolites in blood serum of children with celiac disease.

Objectives: The aim of the study was to determine serum nitric oxide (NO) metabolites and correlate them to gluten-free diet (GFD) compliance, the parameters of morphological and functional condition of the small intestine in patients with celiac disease (CD) in a long-term follow-up.

Patients And Methods: The study included 35 children (age median 8.0 years) with previously diagnosed CD, among them 15 - on a strict GFD and 20 - on a semistrict GFD.

S-nitrosothiols, nitric oxide and proinflammatory cytokines in children with inflammatory bowel disease.

Background: The aim of the study was to investigate the levels of S-nitrosothiols (RSNO) in blood serum of children with inflammatory bowel disease (IBD), nonspecific ulcerative colitis (NUC) and Crohn's disease (CD), and correlate the obtained data with the number of total nitric oxide metabolites (NOx) and proinflammatory cytokines (PC).

Methods: RSNO and NOx were determined by the Griess method and PC by ELISA. We examined 174 children of both genders aged from 6 to 17 years (mean age - 14 years) including 112 children suffering from IBD and 62 children from the control group.

[Staged correction of spinal deformity in a patient with incontinentia pigmenti syndrome].

Case presentation of staged surgical treatment of patients with spinal deformity in incontinentia pigmenti syndrome. As a result of surgical procedure proper sagittal balance of the body was restored.

[Changes of epidermal growth factor level in blood serum, saliva and gastric juice in children with duodenal ulcer].

Aim: The aim of our study is to investigate EGF content in biological mediums in children with duodenum ulcer depending on phase of the disease and different variants of its course.

Materials And Methods: The present study was performed in Federal State Establishment "Nizhniy Novgorod Research Institute of Children Gastroenterology", Nizhniy Novgorod, Russia. 92 children, between the ages of 8 to 17, with duodenum ulcer were under observation.

[Surgical treatment of patients with spinal deformities with shortening of the lower limb].

Aim: Determination of the optimal diagnostic and treatment strategy in patients with scoliosis and having an anatomic shortening of the lower limb.

Patients And Methods: Surgical correction of scoliosis held 8 to patients with lower limb shortening caused by congenital dislocation of the hip (n = 3), anatomic shortening of the lower extremities due to the hip (n = 1), the shin bone (n = 4). Shortening before correction and fixation of scoliosis ranged from 6 to 14 cm, after surgery on the spine has been reduced by 2-4 cm achieved reduction or removal of pelvic obliquity.

[Nitric oxide, its metabolites, and glutathione system in children with chronic viral hepatitis B and C].

Aim: To detect changes in the concentration of nitric oxide and its metabolites--nitrites and nitrates in conjunction with the indices of the glutathione system in the children with chronic hepatitis B and C.

Patients And Methods: In the research took a part 76 patients (boys or girls) with chronic hepatitis B and C aged from 7 up to 16 years. Nitric oxide and its metabolites determined by method of V.

[Content of epidermal growth factor in biosubstrates and macrophage count in defect healing in children and adolescents with duodenal ulcer disease].

The concentrations of epidermal growth factor (EGF) in saliva, gastric juice, and blood and those of macrophages in mucosal biopsy specimens were determined in children with duodenal ulcer disease. The maximum level of EGF was noted in the saliva. There were unidirectional positive changes in the levels of EGF and macrophages during ulcerative defect healing.

[A new procedure for evaluating the severity of childhood celiac disease].

The paper describes a new procedure for evaluating the severity of childhood celiac disease, the basis of which is to determine the salivary activity of the enzyme ornithine decarboxylase (ODC). The salivary ODC activity index of 0.0001 to 0.

[Vascular disturbances in craniovertebral pathology in children and adolescents].

The peculiarities of craniovertebral abnormalities and dysplasias in children and adolescents have been studied. Different diagnostic methods (dopplerography of spinal arteries, ultrasonography, remote infrared thermography, laser doppler flowmetry, etc) were compared. The outlines for treatment the patients with cervical dysplasias are described.

[Halo-traction efficacy in surgery on the cervical spine].

The paper deals with the use of a halo-apparatus in lesions and diseases of the cervical vertebra. The halo-apparatus was used in 70 patients. It was most commonly employed in lesions of the upper cervical vertebra, such as fractures of the odontoid process and C2 vertebral arches.

[The pathogenesis of elevated intracranial pressure in children and adolescents with craniovertebral pathology].

The paper deals with intracranial hypertension in children and adolescents. Thirty-six patients with the upper cervical dysplasia and identified associated intracranial hypertension were examined. Magnetic resonance imaging and functional tests were used.

[Diagnostic value of myeloscintigraphy in lesions and diseases of the spine].

Twenty-seven myeloscintigraphic examinations were carried out in 24 patients aged 6 to 66 with various diseases and involvements of the spine. Seven patients suffered from scoliosis complicated by neurologic symptoms, 2 from compression fractures of the L2 vertebra, 1 from a benign tumor of the spinal cord, 13 from various dislocations of the upper cervical segments of the spine, and 1 from a chronic fracture of the spinous process of C2 vertebra. Myeloscintigraphic examinations revealed different disorders of the spinal cord subarachnoidal space patency.

[Atlanto-axial instability in injuries of the ligament system in children and adolescents].

There has been carried out an experiment with 6 craniovertebral blocks with contrasting of the vertebral arteries and studying of the influence of different damages of ligamentous apparatus on blood flow in vertebral arteries. In all cases there has been discovered significant vertebrogenic influence. Experimental data have been corroborated with clinical material.