Demographic processes and genetic variability of mouse populations at the ecological-geographic periphery.

On the basis of the results of long-term monitoring, the peculiarities of demographic processes in Sylvaemus uralensis Pall. populations under the peripheral ecological-geographic conditions of the area have been studied. Data of the individual marking and ontogenetic history of animals are presented.

[Comparative FISH analysis of C-positive blocks of centromeric chromosomal regions of pygmy wood mice Sylvaemus uralensis (Rodentia, Muridae)].

The composition and homology of centromeric heterochromatin DNA has been compared in representatives of the Asian race and two chromosomal forms (Eastern European and Southern European) of the European race of the pygmy wood mouse Sylvaemus uralensis by means of in situ hybridization with metaphase chromosomes of microdissection DNA probes obtained from centromeric C-blocks of mice of the Southern European chromosomal form and the Asian race. Joint hybridization of both DNA probes yielded all possible variants of centromeric regions in terms of the presence of repetitive sequences homologous to those of some or another dissection region, which indicates a diversity of centromeric regions differing in DNA composition. However, most variations of the fluorescent in situ hybridization (FISH) patterns are apparently related to quantitative differences of repetitive elements of the genome.

Risk factors for stroke in type 2 diabetes mellitus.

Stroke is a serious complication of diabetes but the risk factors for stroke in these patients are not fully defined. The aim of this retrospective study was to investigate the risk factors for stroke in patients with type 2 diabetes mellitus (T2DM). The group comprised 208 patients with T2DM, and the mean duration of follow-up was seven years (range 4-11 years).

[Heterogeneity of diabetes mellitus].

Aim: To define a criterium for differentiation of different types of diabetes mellitus (DM).

Materials And Methods: The condition of immunity, antibodies to the pancreatic island cells, proliferative activity of peripheral blood lymphocytes in response to human immunoglobulin were studied in 152 patients with DM.

Results: Sensitization of lymphocytes to insulin is associated with DM type I.

[Immune system in residents of territories contaminated with radionuclides after Chernobyl accident].

Aim: Study of the immunity and nonspecific defense factors in subjects living at a territory contaminated with radionuclides at a density of 1-5 Ci/km2 after the Chernobyl accident.

Materials And Methods: A total of 144 subjects aged 18 to 82 years living in the Sasovo region of the Ryazan district were examined. Three groups were distinguished with different density of contamination: 1) n = 54, 1-5 Ci/km2; 2) n = 36, conditionally pure territory; and 3) n = 54, living at the interface of the two territories.