In-silico study and in-vitro validations for an affinity of mangiferin with aldose reductase: Investigating potential in tackling diabetic retinopathy.

Type II Diabetes mellitus (T2DM) and associated complications primarily diabetic retinopathy cases are rising with an alarming rate. Prolong hyperglycemia along with the aldose reductase (AR) activity play a pivotal role in the development of oxidative stress in the aqueous humor and diabetic retinopathy. AR catalyzes conversion of glucose into sorbitol and or fructose get diffuse into lens leading to impaired electrolyte balance and cataract formation.

Determination of trace impurities in germanium dioxide by ICP-OES, ICP-MS and ETAAS after matrix volatilization: a long-run performance of the method.

High-purity germanium compounds (e.g. germanium dioxide) are used these days in several applications (e.

Thermal and spectroscopic investigation of europium and samarium sulphates hydrates by TG-FTIR and ICP-MS techniques.

The investigation of europium(III) sulphate hydrate and samarium(III) sulphate hydrate was performed by thermal analysis (TG-DTG) and simultaneous infrared evolved gas analysis-Fourier transformed infrared (EGA-FTIR) spectroscopy. The TG, DTG and DTA curves were recorded at the 25-1400 degrees C in the dynamic air atmosphere by TG/DTA analyser. The infrared evolved gas analysis was obtained on the FTIR spectrometer.

Cadmium uptake by a green alga can be predicted by equilibrium modelling.

Short-term uptake of cadmium by a wild-type (2137) and a cell wall-less strain (CW-2) of Chlamydomonas reinhardtii was examined as a function of Cd speciation in a well-defined, aqueous medium. Internalization fluxes were determined for free cadmium concentrations ranging from 5 x 10(-10) M to 5 x 10(-4) M in the presence of ligands forming both labile and inert hydrophilic complexes. A first-order biological internalization, as predicted by the free ion activity model (FIAM), was observed for both strains.

Development of analytical methods for the determination of sub-ppm concentrations of palladium and iron in methotrexate.

Analytical methods for limit test (1 microgg(-1)) determination of iron and palladium in the drug substance methotrexate (MTX) were developed. The methods developed were based on microwave-assisted, vapor-phase digestion using quartz inserts inside the digestion vessels, followed by instrumental determination. Iron was determined by graphite furnace atomic absorption spectrometry (GFAAS) and palladium by direct current plasma optical emission spectrometry (DCP-OES).

Economic burden and quality of life impairment increase with severity of PD.

Purpose: To define the interrelationship between cost-of-illness, quality of life (QoL) and Parkinson's disease (PD) severity in a common patient management setting in Finland.Scope. Two hundred and sixty consecutive outpatients with idiopathic PD participated.

Bilateral congenital oral mucous extravasation cysts.

This report documents the bilateral presentation of oral mucous extravasation cysts on the left mucobuccal fold and right buccal mucosa of a neonate. The lesions were noted at birth and subsequently enlarged to the point that they interfered with eating. The left lesion ruptured but persisted as an exophytic fibrotic mass.

Three-dimensional computed tomography reconstruction in treatment planning for large ameloblastoma.

A case of an unusually large mandibular ameloblastoma is reported in which standard radiologic examination failed to provide adequate visualization of the tumor's limits because of overlapping structures and the presence of compound shadows. Computed tomography imaging and three-dimensional reconstruction proved invaluable in the treatment planning of this large lesion, because it allowed the surgeon to visualize and comprehend the geography of the tumor and its relationship to surrounding structures and soft tissues and to formulate a surgical plan. Use of this technique helped ensure complete excision of the tumor without excessive removal of uninvolved tissue.