Linear Bidentate Ligands (L) with Two Terminal Pyridyl N-Donor Groups Forming Pt(II)LCl Complexes with Rare Eight-Membered Chelate Rings.

NMR and X-ray diffraction studies were conducted on Pt(II)LCl complexes prepared with the new N-donor ligands N(SOR)Me dpa (R = Me, Tol; n = 2, 4). These ligands differ from N(H)dpa (di-2-picolylamine) in having the central N within a tertiary sulfonamide group instead of a secondary amine group and having Me groups at the 6,6'-positions ( n = 2) or 3,3',5,5'-positions ( n = 4) of the pyridyl rings. The N(SOR)3,3',5,5'-Medpa ligands are coordinated in a bidentate fashion in Pt( N(SOR)3,3',5,5'-Medpa)Cl complexes, forming a rare eight-membered chelate ring.

A Very Rare Example of a Structurally Characterized 3'-GMP Metal Complex. NMR and Synthetic Assessment of Adducts Formed by Guanine Derivatives with [Pt(L)Cl]Cl Complexes with an N,N',N″ Tridentate Ligand (L) Terminated by Imidazole Rings.

[Pt(N(R)-1,1'-Medma)Cl]Cl complexes with tridentate ligands (bis(1-methyl-2-methylimidazolyl)amine, R = H; N-(methyl)bis(1-methyl-2-methylimidazolyl)amine, R = Me) were prepared in order to investigate Pt(N(R)-1,1'-Medma)G adducts (G = monodentate N9-substituted guanine or hypoxanthine derivative). Solution NMR spectroscopy is the primary tool for studying metal complexes of nucleosides and nucleotides because such adducts rarely crystallize. However, [Pt(N(H)-1,1'-Medma)(3'-GMPH)]NO·5HO (5) was crystallized, allowing, to our knowledge, the first crystallographic molecular structure determination for a 3'-GMP platinum complex.

Synthesis and characterization of novel rhenium(I) complexes towards potential biological imaging applications.

Background: Re(I) tricarbonyl complexes exhibit immense potential as fluorescence imaging agents. However, only a handful of rhenium complexes have been utilized in biological imaging. The present study describes the synthesis of four novel rhenium complexes, their characterization and preliminary biological studies to assess their potential as biological imaging agents.