Publications by authors named "Koki Murakami"
Background: Glioblastoma is characterized by neovascularization and diffuse infiltration into the adjacent tissue. T2*-based dynamic susceptibility contrast (DSC) MR perfusion images provide useful measurements of the biomarkers associated with tumor perfusion. This study aimed to distinguish infiltrating tumors from vasogenic edema in glioblastomas using DSC-MR perfusion images.
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- Glioblastoma multiforme (GBM) is a highly aggressive brain tumor that urgently needs new therapies; CAR T cell therapy has shown promise but is costly and time-intensive.
- Researchers are exploring CAR-transduced natural killer (NK) cells as an "off-the-shelf" immunotherapy alternative, which can avoid complications like graft-versus-host disease.
- Both CAR-T and CAR-NK cells targeting the B7-H3 protein demonstrated significant effectiveness in killing GBM cells in lab tests and in animal models, suggesting they could be viable treatment options for this aggressive cancer.
Ga-based liquid metals (LMs) are expected to be suitable for wiring highly deformable devices because of their high electrical conductivity and stable resistance to extreme deformation. Injection and printed wiring, and wiring using LM-polymer composites are the most popular LM wiring approaches. However, additional processing is required to package the wiring after LM patterning, branch and interrupt wiring shape, and ensure adequate conductivity, which results in unnecessary wiring shape changes and increased complexity of the wiring methods.
View Article and Find Full Text PDFStretchable Gas Barrier Films Using Liquid Metal toward a Highly Deformable Battery.
ACS Appl Mater Interfaces
October 2022
Highly deformable batteries that are flexible and stretchable are important for the next-generation wearable devices. Several studies have focused on the stable operation and life span of batteries. On the other hand, there has been less focus on the packaging of highly deformable batteries.
View Article and Find Full Text PDFDirect Wiring of Liquid Metal on an Ultrasoft Substrate Using a Polyvinyl Alcohol Lift-off Method.
ACS Appl Mater Interfaces
February 2022
Article Synopsis
- Recent advancements in wearable and implantable devices have focused on using ultrasoft materials like biological tissues and hydrogels, with Ga-based liquid metals (LMs) being a promising option due to their biocompatibility and softness.
- The study successfully demonstrated transferring liquid metal paste onto these ultrasoft substrates using a polyvinyl alcohol (PVA) film, which allowed for precise, stable wiring patterns, including three-dimensional structures.
- Notably, the method enabled effective nerve stimulation in rats and successful integration of a temperature measurement system, highlighting potential applications in advanced electric devices.
Objective: The efficacy of endovascular treatment for middle cerebral artery (MCA) aneurysms remains controversial. However, recent studies have reported the safety of endovascular treatment for MCA aneurysms. In this study, we studied the efficacy and clinical outcomes of endovascular treatment for MCA aneurysms in our hospital and the morphology and anatomy of MCA aneurysms that were suitable for endovascular treatment.
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