A comprehensive survey analysis focusing on the effect of living literacy on residential environment and health recognition under COVID-19 in Japan.

Appropriate knowledge and actions of residents in housing are expected to reduce health effects, defined as "living literacy." With the spread of COVID-19 and the diversification of lifestyles, a quantitative evaluation of a comprehensive model that includes living literacy in the housing environment is required. In this study, the author conducted two web-based surveys of approximately 2000 different households in Japan during the summer of 2020 and winter of 2021, and a statistical analysis based on the survey results.

Asymmetric Total Synthesis of Toxicodenane A by Samarium-Iodide-Induced Barbier-Type Cyclization and Its Cell-Protective Effect against Lipotoxicity.

The asymmetric total synthesis of toxicodenane A, a sesquiterpenoid expected to be promising for diabetic nephropathy, was achieved. In the synthesis, a samarium iodide (SmI)-induced Barbier-type cyclization and a regio- and stereoselective allylic oxidation followed by a dehydration cyclization were employed as key steps. Furthermore, the first asymmetric syntheses of both enantiomers were accomplished using the previously mentioned synthetic strategy.