Roles of lysophosphatidic acid (LPA) receptor-mediated signaling in cellular functions modulated by endothelial cells in pancreatic cancer cells under hypoxic conditions.

Background: In the tumor environment, malignant characteristics of cancer cells are promoted by stromal cells under hypoxia. It is unknown whether lysophosphatidic acid (LPA) receptor-mediated signaling is involved in the regulation of cellular functions by endothelial cells in pancreatic cancer cells under hypoxic conditions.

Methods: Pancreatic cancer (PANC-1) cells were co-cultured with endothelial (F2) cells and F2 cell supernatants at 21% and 1% O.

Effects of free fatty acid receptor (FFAR) signaling on the modulation of cancer cell functions under hypoxic conditions.

In the tumor environment, hypoxia promotes tumor progression, such as cancer cell growth, migration and chemoresistance. This study aimed to evaluate the roles of free fatty acid receptors (FFARs) in the regulation of cancer cell functions under hypoxic conditions, using fibrosarcoma HT1080 cells. HT1080 cells expressed FFAR1, FFAR2 and FFAR3 genes, but not FFAR4 gene.

Induction of lysophosphatidic acid (LPA) receptor-mediated signaling regulates cell motility and survival to anticancer drugs in cancer cells treated with hydrogen peroxide.

Hydrogen peroxide (HO) is one of reactive oxygen species (ROS) and promotes malignant properties of cancer cells. Lysophosphatidic acid (LPA) signaling via LPA receptor (LPA to LPA) regulates a variety of cellular functions, such as cell growth, migration and differentiation. This study aimed to evaluate the effects of LPA receptors on the cell motility and survival to anticancer drugs by HO in colon cancer DLD-1 cells.

Materials informatics approach using domain modelling for exploring structure-property relationships of polymers.

In the development of polymer materials, it is an important issue to explore the complex relationships between domain structure and physical properties. In the domain structure analysis of polymer materials, H-static solid-state NMR (ssNMR) spectra can provide information on mobile, rigid, and intermediate domains. But estimation of domain structure from its analysis is difficult due to the wide overlap of spectra from multiple domains.

Protective Effect of Ferulic Acid against Hydrogen Peroxide Induced Apoptosis in PC12 Cells.

Ferulic Acid (FA) is a highly abundant phenolic phytochemical which is present in plant tissues. FA has biological effects on physiological and pathological processes due to its anti-apoptotic and anti-oxidative properties, however, the detailed mechanism(s) of function is poorly understood. We have identified FA as a molecule that inhibits apoptosis induced by hydrogen peroxide (HO) or actinomycin D (ActD) in rat pheochromocytoma, PC12 cell.

Advanced oxidation mechanism of UV photolysis of electrochemically generated free bromine.

In recent times, some researchers have successfully demonstrated the efficacy of UV photolysis of electrochemically generate free chlorine (UV/electro-chlorine) as for an advanced oxidation process. Since bromine as well as chlorine is an element belonging to halogen, it is expected that UV photolysis of electrochemically generated free bromine (UV/electro-bromine) also shows an advanced oxidation effect. To elucidate the feasibility of UV/electro-bromine system, its advanced oxidation mechanism was investigated using radical probes of 1,4-dioxane and nitrobenzene.

Duration of cleavage cycles and asymmetry in the direction of cleavage waves prior to gastrulation inXenopus laevis.

The animal and the vegetative side of 15 embryos ofXenopus laevis were studied from the 5th cleavage to gastrulation by means of time-lapse cinematography. The duration of cleavage cycles, defined for the embryo as a whole as the period between the earliest blastomere divisions of one cycle to those of the next, varies quite a lot between individual embryos, both with respect to synchronous and lengthened cycles. Cycle lengthening may start at either cycle 10, 11 or 12.

Cinematographic observation of an "activation wave" (AW) on the locally inseminated egg ofXenopus laevis.

Shortly after local artificial insemination, but well before egg rotation,Xenopus eggs show a wave-like propagation of dark-light-dark zones from the site of sperm entrance. This presumably reflects the movement of the front of cortical granule breakdown.