Publications by authors named "Koki Agui"
Bioorg Med Chem Lett
May 2024
Article Synopsis
- Basidalin, derived from the mushroom Leucoagaricus naucina, shows strong antiproliferative effects against human cancer cell lines, building on its known antibacterial and antitumor properties in murine models.
- The study highlights that basidalin’s anticancer action is linked to the induction of autophagy, with increased LC3-II levels and enhanced autophagic flux occurring independently of mTOR pathways.
- Additionally, the effectiveness of basidalin and its analogs in combating cancer cells is tied to their structural features, specifically a formyl group that influences their ability to induce autophagy and inhibit cell growth.
