[Effect of dichloroethane on the hydroxylating and conjugating activity of the membranes of the cytoplasmic network of liver tissue].

The hydroxylating and conjugating activities of the cytoplasmic network membranes in the rat liver tissues were studied as affected by dichloroethane. Administration of this substance decreases the monooxygenase and uridine diphosphate glucuronyl transferase activities in the tissue under study. The reduced content of cytochrome P450 is the earliest index of a decrease in the hydroxylating activity of the liver tissue.

[Therapeutic effectiveness of acetylcysteine in acute dichloroethane poisoning].

With its multiple administration acetylcysteine is shown to display a marked curative effect in acute poisoning of animals (rats, mice, rabbits) with ethylene dichloride. It increases the survival of animals and largely prevents disorders in hemopoiesis and in the blood coagulation system, minimizing toxic lesions of the liver and kidneys.