Publications by authors named "Kok Wai Giang"
Long-term survival in patients with univentricular heart: A nationwide, register-based cohort study.
Int J Cardiol Congenit Heart Dis
March 2024
Background: Children with univentricular heart (UVH) have a limited life expectancy without early treatment. Long-term survival in UVH, in an unselected nationwide cohort, is unclear.
Objectives: To determine long-term survival in patients with UVH including non-operated patients compared with a control population in Sweden.
Aims: Patients with congenital heart disease (CHD) have an increased risk of developing acquired cardiovascular diseases. However, the risk of venous thromboembolism (VTE) in patients with CHD is unknown. We aimed to investigate the incidence and risk of VTE in patients with CHD compared with matched controls without CHD.
View Article and Find Full Text PDFAims: There is scarce knowledge about the association between social factors and mid-term outcome in older patients undergoing transaortic valve implantation (TAVI). Our aim in this study is to explore associations between marital status, educational level, and mortality risk in patients after TAVI.
Methods And Results: Patients aged ≥65 who underwent TAVI in Sweden during 2014-2020 were identified from the SWEDEHEART registry.
Article Synopsis
- * Data was collected from Swedish health registries, and the analysis revealed a 5.16 times higher hazard ratio for stroke in patients with both CHD and AF, with even higher ratios in complex CHD cases.
- * The results suggest that younger patients with CHD and AF face a notably increased risk of ischemic stroke, highlighting the need for further research to validate these findings.
Aims: Individuals with congenital heart disease (CHD) are at an increased risk for cancer. As cancer survival rates improve, the prevalence of late side effects, such as heart failure (HF), is becoming more evident. This study aims to evaluate the risk of developing HF following a cancer diagnosis in patients with CHD, compared with those without CHD and with CHD patients who do not have cancer.
View Article and Find Full Text PDFCorrigendum to "Risk of cancer in young and older patients with congenital heart disease and the excess risk of cancer by syndromes, organ transplantation and cardiac surgery: Swedish health registry study (1930-2017)" [The Lancet Regional Health-Europe 18 (2022) 100407].
Lancet Reg Health Eur
May 2024
Article Synopsis
- The text indicates that there is a correction made to a previously published article.
- The article can be identified using its DOI (Digital Object Identifier) number: 10.1016/j.lanepe.2022.100407.
- The correction is likely to address an error or oversight from the original publication.
Article Synopsis
- Patients with congenital heart disease (CHD) have a higher cancer risk and were found to have a lower median age of cancer diagnosis (13 years) compared to non-CHD controls (24.6 years).
- Despite the increased cancer incidence, the overall mortality risk for CHD patients with cancer is not significantly different from that of non-CHD patients when excluding those with genetic syndromes and transplant recipients.
- The most common fatal cancers among CHD patients included unspecified cancers, eye and central nervous system tumors, and blood-related malignancies, with 18.3% of CHD patients diagnosed with cancer ultimately dying from it.
Article Synopsis
- * Analysis was conducted on data from nearly 25,000 CHD patients and over 270,000 controls, revealing a higher incidence of diabetes (8.4% for CHD patients vs. 5.6% for controls) and an increased mortality rate attributed to diabetes in CHD patients.
- * Findings indicate that the risk of diabetes is greater in more recent generations of CHD patients and those with more complex heart defects, highlighting the need for targeted health monitoring and management strategies.
Article Synopsis
- A study examined the survival rates of patients with congenital heart disease (CHD) and Down syndrome (DS) compared to those with CHD without DS and matched controls from the general population.
- Researchers found that patients with CHD-DS had a mortality risk 25 times higher than controls and twice as high as patients with CHD without DS.
- There was a notable improvement in survival for patients with CHD-DS born after 1990, suggesting advancements in congenital heart care may have positively influenced their outcomes.
Socioeconomic factors and long-term mortality risk after surgical aortic valve replacement.
Int J Cardiol Cardiovasc Risk Prev
December 2023
Background: There is scarce knowledge about the association between socioeconomic status and mortality in patients undergoing surgical aortic valve replacement. This study explores the associations between income, education and marital status, and long-term mortality risk.
Methods: In this national registry-based observational cohort study we included all 14,537 patients aged >18 years who underwent isolated surgical aortic valve replacement for aortic stenosis in Sweden 1997-2020.
Article Synopsis
- Mortality rates for pediatric patients with tetralogy of Fallot (TOF) have significantly decreased since surgical interventions began in the 1950s, yet comprehensive survival data in Sweden remains limited.
- This study aimed to analyze survival trends of children with TOF and compare them to similarly matched controls using a nationwide dataset from Sweden spanning nearly five decades.
- The results indicated that of 1,848 patients with TOF, 15.5% died during follow-up, with a notable 10.1% mortality rate in those who underwent surgery, highlighting improved survival rates over different birth periods.
Background: Improvements in diagnosis, intervention, and care of congenital heart disease (CHD) have led to increased survivability and lifelong dependence on healthcare. This study aims to determine the extensiveness of inpatient care episodes across different life-stages and CHD severity compared to matched controls, and to explore how healthcare utilization among pediatric CHD cases have changed over time.
Methodology: National registry data was used to conduct a 1:9 matching analysis with age and sex matched controls.
Article Synopsis
- The study examines the long-term survival and mortality rates of adult patients with congenital heart disease (ACHD) who were born between 1950 and 1999, showing that 97% of these children now reach adulthood.
- Data from the Swedish health registers reveal higher mortality rates in ACHD patients compared to matched controls, with a notable 75% of these patients living into their 50s or beyond.
- The research indicates that those with more complex congenital defects face significantly higher risks of mortality compared to those with less severe conditions, highlighting the importance of continued monitoring and care for this population.
Article Synopsis
- A study investigated the risk of chronic kidney disease (CKD) in young patients with congenital heart disease (CHD) compared to healthy controls, using data from Swedish health registers.
- It found that patients with CHD had a significantly higher risk of developing CKD (6.4 times more likely) during a median follow-up of 13.5 years, especially those with severe heart defects.
- Although the overall risk of CKD is low, the study highlights the need for more guidelines and monitoring for CKD in patients with CHD.
Aims: Our objective was to assess changes in the birth prevalence of CHD over a half-century in a high-resource, nationwide setting, as well as changes in the prevalence of cardiac interventions in this population.
Methods And Results: The Swedish National Patient and Cause of Death registers were linked to estimate the annual rates of CHD and cardiac interventions among live-born infants from 1970 to 2017. Additionally, separate estimates were obtained by lesion complexity, from mild to the most complex forms of CHD.
Fractures in patients with and without congenital heart disease - A nationwide register-based cohort study.
Int J Cardiol Congenit Heart Dis
December 2022
Background: Patients with congenital heart disease (CHD) now live longer; thus, there is a need to assess factors related to ageing in this group. We aimed to determine the incidence and risk of fractures in patients with CHD.
Methods: Data of patients with CHD were retrieved from the National Swedish Patient Register (n = 83,084) and matched according to birth year and sex, with nearly nine controls per patient from the Total Population Register in Sweden (n = 719,447).
Risk for first onset depression in adults with congenital heart disease.
Int J Cardiol Congenit Heart Dis
September 2022
Background: The long-term risk for depression among adults with congenital heart disease (ACHD) is unclear. Therefore, we assessed the risk for first onset of serious depression in patients with ACHD compared with a sex- and age-matched control population without a congenital heart disease (CHD) diagnosis.
Methods: We extracted all patients with CHD born from 1970 to 1999 who survived until age 18 years from the Swedish National Patient Register.
Background: Increasing survival of patients with congenital heart disease (CHD) will result in an increased risk of age-dependent acquired diseases later in life. We aimed to investigate the risk of cancer in young and older patients with CHD and to evaluate the excess risk of cancer by syndromes, organ transplantation and cardiac surgery.
Methods: Patients with CHD born between 1930 and 2017 were identified using Swedish Health Registers.
Aims: This study was performed to compare trends in home-time for patients with heart failure (HF) between those of working age and those of retirement age in Sweden from 1992 to 2012.
Methods And Results: The National Inpatient Register (IPR) was used to identify all patients aged 18 to 84 years with a first hospitalization for HF in Sweden from 1992 to 2012. Information on date of death, comorbidities, and sociodemographic factors were collected from the Swedish National Register on Cause of Death, the IPR, and the longitudinal integration database for health insurance and labour market studies, respectively.
Aims: To improve short-and long-term predictions of mortality and atrial fibrillation (AF) among patients with congenital heart disease (CHD) from a nationwide population using neural networks (NN).
Methods And Results: The Swedish National Patient Register and the Cause of Death Register were used to identify all patients with CHD born from 1970 to 2017. A total of 71 941 CHD patients were identified and followed-up from birth until the event or end of study in 2017.
Aims: Atrial fibrillation (AF) is associated with arterial thromboembolism, mainly ischaemic stroke, while venous thromboembolism (VTE) in AF is less well studied. The aim of this study, therefore, was to examine the relationship between AF and VTE, including pulmonary embolism (PE) and deep venous thrombosis (DVT).
Methods And Results: AF cases without previous VTE, ischaemic stroke or pulmonary arterial hypertension were identified from the Swedish Inpatient Registry between 1987 and 2013 and compared to two population controls per case without AF matched for age, sex, and county with respect to the incidence of VTE, PE, and DVT.
Background Patients with congenital heart disease (CHD) are at increased risk of developing ischemic stroke (IS) compared with controls without CHD. However, the long-term outcomes after IS, including IS recurrence and mortality risk, remain unclear. Methods and Results We identified all patients with CHD in Sweden who were born between 1930 and 2017 using the Swedish National Patient Register and the Cause of Death Register.
View Article and Find Full Text PDFBackground: Congenital heart disease (CHD) is a lifelong predisposing condition for infective endocarditis (IE). As a consequence of advances in pediatric care, the number of adults with CHD is now exceeding the number of children. The goal of the present study was to determine the cumulative incidence of IE in patients with CHD and detect temporal changes compared with controls.
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