Publications by authors named "Kok Keong Loke"

Article Synopsis
  • Functional genomics combines molecular biology and bioinformatics to study how genetic elements influence an organism's physiology, especially using data from DNA sequencing.
  • With the rise of big biological data, computer scientists and mathematicians are essential for developing tools and software to manage and analyze this information.
  • The chapter explores functional genomics in systems biology with examples in human disease, agriculture, and antibiotic discovery, and includes a case study on the transcriptomics of an aromatic herbal plant to investigate how elicitation affects volatile organic compound production.
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Background: Jasmonic acid (JA) and its derivative, methyl JA (MeJA) are hormonal cues released by plants that signal defense response to curb damages from biotic and abiotic stresses. To study such response, a tropical herbal plant, , which possesses pungent smell and various bioactivities including antimicrobial and anticancer, was treated with MeJA. Such elicitation has been performed in hairy root cultures and plants such as Arabidopsis and rice, yet how MeJA influenced the proteome of an herbal species like is unknown.

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Article Synopsis
  • Proteomics research faces challenges due to limited protein sequence databases for non-model species like herbs, but using translated transcriptome databases can help.
  • A study utilized SWATH-MS technology alongside transcriptome profiling to analyze the proteome of a tropical herb, marking a first for this type of analysis.
  • The research investigated how the phytohormone methyl jasmonate affects protein changes, and the findings were shared in the ProteomeXchange Consortium with the identifier PXD005749.
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sp. produces bioactive compounds with a broad spectrum of activities. SUK12 has been identified as a novel endophytic bacteria isolated from ethnomedicinal plant , and was found to produce the phenazine class of biologically active antimicrobial metabolites.

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Mangosteen ( L.) is known for its delectable taste and contains high amount of xanthones which have been reported to possess anti-cancer, anti-inflammatory and other bioactive properties. However, stage-specific regulation of mangosteen fruit ripening has never been studied in detail.

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The "Queen of Fruits" mangosteen ( L.) produces commercially important fruits with desirable taste of flesh and pericarp rich in xanthones with medicinal properties. To date, only limited knowledge is available on the cytogenetics and genome sequences of a common variety of mangosteen (Abu Bakar et al.

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Mangosteen ( Linn.) is an ultra-tropical tree characterized by its unique dark purple fruits with white flesh. The xanthone-rich purple pericarp tissue contains valuable compounds with medicinal properties.

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Background: is an herbal plant in the Polygonaceae family which is rich in ethnomedicinal plants. The chemical composition and characteristic pungent fragrance of have been extensively studied due to its culinary and medicinal properties. There are only a few transcriptome sequences available for species from this important family of medicinal plants.

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is an herbal plant that grows in Southeast Asian countries and traditionally used as medicine. This plant produces diverse secondary metabolites such as phenolic compounds and their derivatives, which are known to have roles in plant abiotic and biotic stress responses. Methyl jasmonate (MeJA) is a plant signaling molecule that triggers transcriptional reprogramming in secondary metabolism and activation of defense responses against many biotic and abiotic stresses.

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Mangosteen (Garcinia mangostana Linn.) is a tropical tree mainly found in South East Asia and considered as "the queen of fruits". The asexually produced fruit is dark purple or reddish in color, with white flesh which is slightly acidic with sweet flavor and a pleasant aroma.

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Carnivorous plants have the ability to capture and digest insects for nutrients, which allows them to survive in land deprived of nitrogenous nutrients. Nepenthes spp. are one of the carnivorous plants, which uniquely produce pitcher from the tip of an elongated leaf.

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Polygonum minus plant is rich in secondary metabolites, especially terpenoids and flavonoids. Present study generates transcriptome resource for P. minus to decipher its secondary metabolite biosynthesis pathways.

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Functional genomics has proven to be an efficient tool in identifying genes involved in various biological functions. However the availability of commercially important seaweed Eucheuma denticulatum functional resources is still limited. EuDBase is the first seaweed online repository that provides integrated access to ESTs of Eucheuma denticulatum generated from samples collected from Kudat and Semporna in Sabah, Malaysia.

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