Publications by authors named "Koji Yatsu"
Article Synopsis
- * Among the 404 isolates obtained, 126 (31%) were identified as positive for CTX-M, with the CTX-M-9 group being the most prevalent.
- * Plasmid analysis revealed complex networks indicating potential gene transfer mechanisms between different bacterial species, which could impact public health in urban settings.
Article Synopsis
- The study investigates the presence of antimicrobial resistance genes (ARGs) in the effluents of urban wastewater treatment plants (WWTPs) around the Tama River and Tokyo Bay, highlighting the potential link between wastewater discharge and increased risk of infectious diseases.
- Metagenomic DNA sequencing revealed that the sulfonamide resistance gene was the most common, with notable seasonal variations in the prevalence of certain resistance genes, indicating environmental factors may influence ARG distribution.
- The research underscores the importance of monitoring ARGs and heavy-metal resistance genes in urban wastewater systems, suggesting it could be crucial for tracking the spread of antimicrobial resistance in the environment.
The worldwide eruption of coronavirus disease 2019 (COVID-19) that began in Wuhan, China in late 2019 reached 10 million cases by late June 2020. In order to understand the epidemiological landscape of the COVID-19 pandemic, many studies have attempted to elucidate phylogenetic relationships between collected viral genome sequences using haplotype networks. However, currently available applications for network visualization are not suited to understand the COVID-19 epidemic spatiotemporally due to functional limitations that motivated us to develop Haplotype Explorer, an intuitive tool for visualizing and exploring haplotype networks.
View Article and Find Full Text PDFA coronavirus disease (COVID-19) genome surveillance has been conducted at four international airports in Japan, revealing a potential imported COVID-19 risk from multiple countries. The quarantine surveillance based on genome sequencing can enhance sequencing efforts worldwide, as returning travelers may serve as excellent sentinels for the global pandemic.
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- The first COVID-19 case in Japan was reported on January 15, 2020, and multiple clusters emerged by the end of February, prompting the government to conduct active surveillance.
- Despite efforts to contain the virus, cases continued to rise until early April, with many instances lacking clear infection routes.
- Genome sequencing of SARS-CoV-2 from early cases revealed at least two distinct introductions of the virus into Japan—first from China and later from Europe—contributing to the spread within the country.
In insects, the voltage-gated sodium channel (VGSC) is the primary target site of pyrethroid insecticides. Various amino acid substitutions in the VGSC protein, which are selected under insecticide pressure, are known to confer insecticide resistance. In the genome, the VGSC gene consists of more than 30 exons sparsely distributed across a large genomic region, which often exceeds 100 kbp.
View Article and Find Full Text PDFAeromonas hydrophila and Aeromonas caviae adapt to saline water environments and are the most predominant Aeromonas species isolated from estuaries. Here, we isolated antimicrobial-resistant (AMR) Aeromonas strains (A. hydrophila GSH8-2 and A.
View Article and Find Full Text PDFAntimicrobial resistance genes (ARGs) and the bacteria that harbor them are widely distributed in the environment, especially in surface water, sewage treatment plant effluent, soil, and animal waste. In this study, we isolated a KPC-2-producing strain (GSU10-3) from a sampling site in Tokyo Bay, Japan, near a wastewater treatment plant (WWTP) and determined its complete genome sequence. Strain GSU10-3 is resistant to most β-lactam antibiotics and other antimicrobial agents (quinolones and aminoglycosides).
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