Publications by authors named "Koji Shirosaki"
Article Synopsis
- Short bowel syndrome (SBS) is a rare condition where patients experience malabsorption due to significant removal of the small intestine; treatment mainly focuses on supportive care, supplementation, and managing complications.
- Despite advancements in parenteral nutrition and intestinal medication, prognosis for SBS patients remains poor, with intestinal transplantation being the only curative option but with unsatisfactory outcomes.
- Research on intestinal organoids is paving the way for new regenerative therapies, including "tissue-engineered small intestine" concepts, which aim to recreate functional small intestine structures, although challenges still need addressing before widespread application.
Aim: To evaluate the use of donor-derived cell-free DNA (dd-cfDNA) in diagnosing graft injuries in Japanese liver transplantation (LTx), including family-related living donors.
Methods: A total of 321 samples from 10 newly operated LTx recipients were collected to monitor the early dynamics of dd-cfDNA levels after LTx. Fifty-five samples from 55 recipients were collected during protocol biopsies (PB), whereas 36 samples from 27 recipients were collected during event biopsies, consisting of 11 biopsy-proven acute rejection (AR), 20 acute dysfunctions without rejection (ADWR), and 5 chronic rejections.