Urinary 8-hydroxydeoxyguanosine levels and psychological reactions after sleep deprivation.

The aim of this study was to investigate whether changes in urinary 8-hydroxydeoxyguanosine (8-OH-dG), an oxidative stress indicator, occur or not, and how psychological reactions change, after one night of sleep deprivation (SD) and after 7 hour recovery sleep opportunities during three recovery days. Twenty healthy subjects participated in this study. We measured their urinary 8-OH-dG levels and psychological reactions using the Profile of Mood States (POMS) for 5 days: on the baseline day, the post-vigil day, and on 3 recovery days after SD.