Publications by authors named "Koji Matsumoto"
Article Synopsis
- Gastrointestinal stromal tumors (GISTs) are rare cancers linked to mutations in the c-KIT gene, with one common mutation being a deletion in exon 11, as seen in an 82-year-old male patient diagnosed in June 2023.
- The patient subsequently received a low-dose imatinib treatment protocol, starting at 400 mg/day and tapering down to 200 mg/day, which resulted in a reduction of the tumor size over several months.
- The study suggests that low-dose imatinib can be an effective treatment option for GIST patients with the W557_K558 deletion, especially for those who cannot tolerate higher doses.
Article Synopsis
- Co-infections with multiple HPV genotypes in Japan are linked to increased sexual activity, with a study analyzing data from 8,128 women under 40 diagnosed with cervical abnormalities from 2012 to 2023.
- Significant declines in multiple HPV infections were observed across different categories of cervical disease (CIN1/2, CIN3/AIS, ICC) over the past decade.
- The study suggests that this decline may correlate with reduced sexual activity among Japanese women, as indicated by a survey of sexual behavior showing a strong link between the number of sexual partners and increased HPV infections.
Article Synopsis
- The study examines how the preoperative Spine Instability Neoplastic Score (SINS) relates to surgical decisions and patient outcomes in spinal metastases patients.
- The research involved 317 patients and assessed various factors like surgery type, existing conditions, and postoperative health indicators over 6 months.
- Findings revealed that SINS did not correlate with life expectancy, all patient-reported outcomes improved post-surgery, and surgical approach (especially fusion vs. non-fusion) didn't significantly impact these outcomes.
Article Synopsis
- The study investigated whether prior adjacent vertebral fractures (AVF) influence the development of new AVFs after balloon kyphoplasty (BKP) in patients with a history of fractures.
- Data from 133 patients undergoing BKP revealed no significant difference in AVF occurrence between those with previous fractures (Group P) and those without (Group C), although Group P had lower bone quality and more prior fractures.
- Within Group P, previously fractured vertebrae had a significantly lower incidence of new AVFs compared to contralateral non-fractured vertebrae, indicating a potential protective effect of prior fractures against further AVFs.
Clinical benefits of adding olanzapine to 5-HT receptor antagonist, NK receptor antagonist, and dexamethasone for the prevention of nausea and vomiting in highly emetogenic chemotherapy: a systematic review and meta-analysis of the Clinical Practice Guidelines for Antiemesis 2023 from the Japan Society of Clinical Oncology.
Michiyasu Murakami Yoshiharu Miyata Kazuhisa Nakashima Masakazu Abe Junichi Nishimura Koji Matsumoto Yoko Matsumoto
Int J Clin Oncol
January 2025
Article Synopsis
- Olanzapine is an atypical antipsychotic that helps prevent nausea and vomiting, particularly after highly emetogenic chemotherapy (HEC), but it can cause side effects like hyperglycemia and drowsiness.
- A systematic review and meta-analysis assessed the effectiveness of olanzapine combined with standard triplet antiemetic therapy compared to triplet therapy alone, focusing on outcomes like nausea control and adverse effects.
- Results showed that adding olanzapine significantly improved nausea and vomiting prevention in both acute and delayed phases with minimal adverse effects, indicating it can be beneficial for patients undergoing HEC.
Efficacy and safety of multi-day antiemetic treatment for patients undergoing multi-day chemotherapy: a systematic review of Clinical Practice Guidelines for Antiemesis 2023 from Japan Society of Clinical Oncology.
Kazuhisa Nakashima Saki Harashima Rena Kaneko Ryuhei Tanaka Masakazu Abe Koji Matsumoto Yoko Matsumoto
Int J Clin Oncol
January 2025
Article Synopsis
- Research lacks a standardized multi-day antiemetic regimen for chemotherapy, making it difficult to assess efficacy and safety.
- A comprehensive search revealed no direct comparisons between multi-day and single-day antiemetic regimens, with variations in study quality and treatment protocols hindering robust analysis.
- Preliminary findings indicate that three-drug combination therapies, particularly using aprepitant, may outperform two-drug regimens; further research is needed to better define antiemetic approaches for multi-day chemotherapy.
Article Synopsis
- The study aimed to assess the effectiveness and safety of robot-assisted radical hysterectomy (RARH) in treating cervical cancer, comparing it to traditional surgical methods.
- A total of 100 patients underwent RARH, achieving a high success rate with minimal blood loss and low recurrence rates after 2 years.
- Results showed strong oncological outcomes, with RARH yielding excellent recurrence-free survival (RFS) and overall survival (OS) rates, suggesting its viability as a surgical option for cervical cancer.
Article Synopsis
- Imlunestrant is a next-generation oral selective estrogen receptor degrader being tested in the EMBER trial for patients with ER+ advanced breast cancer and endometrioid endometrial cancer (EEC).
- The trial involves a dose-escalation design to determine optimal doses and measure safety, pharmacokinetics, and anticancer effects, focusing specifically on patients who have already undergone certain previous treatments.
- Results showed manageable side effects and some evidence of antitumor activity, with better outcomes observed when imlunestrant was combined with abemaciclib compared to imlunestrant alone.
[Evaluation of the Latest Motion Correction Techniques in Periodically Rotated Overlapping ParallEL Lines with Enhanced Reconstruction (PROPELLER) Imaging across Different Vendors].
Nihon Hoshasen Gijutsu Gakkai Zasshi
November 2024
Article Synopsis
- The study aimed to assess the effectiveness of the PROPELLER MRI technology from four different vendors in handling head movements during scans.
- Images were taken from a brain-simulating phantom using devices from Canon, GE, Philips, and Siemens, and evaluated for sensitivity to different types of head motion.
- Results showed that while Canon performed well with small movements, GE's use of deep learning improved image correction, Philips varied in effectiveness, and Siemens was effective against larger movements, indicating the technology’s potential for clinical use despite patient movement.
Efficacy and safety of dexamethasone sparing for the prevention of nausea and vomiting associated with moderately emetogenic chemotherapy: a systematic review and meta-analysis of Clinical Practice Guidelines for Antiemesis 2023 from Japan Society of Clinical Oncology.
Kazuhisa Nakashima Ayako Yokomizo Michiyasu Murakami Kenji Okita Makoto Wada Koji Matsumoto Yoko Matsumoto
Int J Clin Oncol
December 2024
Article Synopsis
- Palonosetron is a second-generation anti-nausea drug that might be more effective than first-generation medications, and this study explores how dexamethasone (DEX) works with it during chemotherapy.
- Researchers compared the effects of giving DEX for 1 day versus 3 days in preventing nausea and vomiting after moderately emetogenic chemotherapy (MEC), using data from studies published between 1990 and 2020.
- The findings showed that while the 3-day DEX group had a higher rate of no vomiting, there were no major differences in most anti-nausea effects, suggesting that DEX treatment could be shortened to just 1 day when paired with palonosetron.
Article Synopsis
- Phase III KEYNOTE-048 study compared the effectiveness of pembrolizumab, pembrolizumab-chemotherapy, and cetuximab-chemotherapy (EXTREME) in Japanese patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) over 5 years.
- Results showed that patients receiving pembrolizumab had significantly higher 5-year overall survival rates compared to those on EXTREME, indicating its potential as a better first-line treatment option.
- Pembrolizumab-chemotherapy also demonstrated durability, but its survival rates were less consistent compared to pembrolizumab alone in the same population.
Article Synopsis
- - The study focuses on the effectiveness and safety of dexamethasone-sparing antiemetic therapies, particularly neurokinin-1 antagonists (NKRA), for preventing chemotherapy-induced nausea and vomiting (CINV) in patients undergoing highly emetogenic chemotherapy (HEC).
- - A systematic review of literature identified and analyzed two studies involving anthracycline-cyclophosphamide and cisplatin-based regimens; while no significant differences in vomiting prevention were found, some outcomes related to nausea showed variability.
- - The review concludes that dexamethasone-sparing antiemetic therapies can be effective in preventing CINV for HEC, particularly in patients receiving anthracycline-cyclophosphamide
Article Synopsis
- Sacituzumab govitecan (SG) is an antibody-drug conjugate approved for treating metastatic triple-negative breast cancer (mTNBC) in various regions, with its safety and effectiveness evaluated in a Japanese study (ASCENT-J02).
- The study consisted of a phase 1 trial that determined the recommended dose (10 mg/kg), followed by a phase 2 trial focusing on the drug's efficacy and safety in patients with previously treated mTNBC.
- Results showed a 25.0% objective response rate at a median follow-up of 6.1 months, with manageable safety outcomes and no significant new safety concerns, confirming SG's efficacy and safety profile similar to earlier studies.
Article Synopsis
- The phase 3 KEYNOTE-355 study showed that pembrolizumab combined with chemotherapy significantly improved progression-free survival (PFS) and overall survival (OS) in patients with untreated, advanced triple-negative breast cancer and high PD-L1 levels compared to placebo with chemotherapy.
- Approximately 64% of patients enrolled in Asian countries, such as Hong Kong, Japan, and Malaysia, had tumors with a PD-L1 combined positive score of 1 or higher, with 35% having a score of 10 or higher.
- Treatment with pembrolizumab plus chemotherapy resulted in manageable side effects, with similar rates of grade 3/4 adverse events compared to the placebo group, indicating a favorable benefit-risk profile.
Defining the clinical benefits of adding a neurokinin-1 receptor antagonist to control chemotherapy-induced nausea and vomiting in moderately emetogenic chemotherapy: a systematic review and meta-analysis of the clinical practice guidelines for antiemesis 2023 from the Japan society of clinical oncology.
Toshinobu Hayashi Shun Yamamoto Yoshiharu Miyata Masayuki Takeda Masakazu Abe Koji Matsumoto Yoko Matsumoto
Int J Clin Oncol
November 2024
Article Synopsis
- Chemotherapy-induced nausea and vomiting (CINV) negatively impacts patient quality of life, leading to a study that evaluated the effectiveness of adding neurokinin-1 receptor antagonists (NK1RAs) to existing antiemetic treatments for patients undergoing moderately emetogenic chemotherapy (MEC).
- A systematic review of clinical studies identified 15 randomized controlled trials involving over 4,400 patients, revealing that triplet antiemetic regimens including NK1RAs significantly improved complete response and complete control of nausea compared to doublet regimens, without increasing adverse events.
- While the addition of NK1RA shows promise for enhancing antiemetic efficacy in carboplatin-based chemotherapy, further research is needed
Article Synopsis
- This study focused on the reliability of measuring the dimensions of the anterior talofibular ligament (ATFL) footprint using three-dimensional MRI, which is crucial for effective ankle ligament repair.
- 20 ankles were analyzed, revealing the sizes of the single-bundle and double-bundle ligament footprints, with specific measurements for both fibular and talar footprints.
- The results showed excellent reliability in measurements between tests and between different raters, indicating that 3D MRI is a valuable tool for assessing ligament anatomy in vivo.
Article Synopsis
- Palbociclib combined with tamoxifen was tested in a phase 3 study involving 184 women with HR+/HER2- advanced breast cancer to evaluate its efficacy and safety compared to tamoxifen alone.
- The results showed a significant improvement in progression-free survival (PFS), with a median of 24.4 months for the palbociclib-tamoxifen group versus 11.1 months for the placebo-tamoxifen group.
- While overall survival (OS) data is still being gathered, there is a trend suggesting palbociclib-tamoxifen may also reduce mortality risk, though neutropenia was a common severe side effect.
Article Synopsis
- A study evaluated the reliability of measuring lateral ankle ligament attachment locations using 3D magnetic resonance imaging (MRI) in 54 participants with healthy ankles, averaging 43 years old.
- Measurements were taken for the anterior talofibular ligament and calcaneofibular ligament attachments, revealing high intrarater and interrater reliability.
- The study concluded that the measurement method provides dependable anatomical data for the lateral ankle ligaments, enhancing understanding of their location in vivo.
Article Synopsis
- The study investigated the postoperative outcomes for patients with spinal metastases from prostate cancer, focusing on improvements in their quality of life and other patient-oriented assessments.
- Conducted across 35 centers, the research assessed 413 patients, with 41 specifically having prostate cancer, and followed them for at least a year following surgery using various evaluation methods.
- Results showed significant improvements in neurological function, quality of life, and patient motivation post-surgery, indicating that surgical intervention is beneficial for these patients.
Article Synopsis
- GAD and SAD are two types of anxiety disorders, where GAD is more generalized, while SAD is specific to social situations.
- This study involved a comparison of brain function among patients with SAD, GAD, and healthy individuals using resting-state functional magnetic resonance imaging.
- It identified significant differences in brain connectivity, notably in the right nucleus accumbens and thalamus, which can help distinguish between SAD and GAD, offering insights into their neurobiological underpinnings.
Article Synopsis
- The study compares brain functions in major depressive disorder (MDD) and social anxiety disorder (SAD) using resting-state fMRI, aiming to identify differences and commonalities in their brain activity patterns.
- Results indicated that both disorders displayed abnormal brain activity in certain regions, with MDD patients showing more pronounced activity in the right superior frontal gyrus compared to SAD patients, while specific functional connectivity in SAD was linked to depressive symptoms.
- Although the findings highlight differences at the regional level, both disorders exhibited similar network-level brain function patterns, suggesting both shared and unique neurobiological characteristics.
Article Synopsis
- The study aimed to determine minimal clinically important differences (MCIDs) for patients undergoing surgery for spinal metastases to improve patient care by linking quality of life assessments with clinical outcomes.
- A total of 171 patients were evaluated pre- and post-surgery using various scales, leading to the identification of specific MCID values for different quality of life aspects based on their treatment outcomes.
- The study successfully established both anchor-based and distribution-based MCIDs for surgical interventions, which can help in assessing patient progress and overall treatment effectiveness.
Article Synopsis
- - The Japan Society of Clinical Oncology updated its 2023 Clinical Practice Guidelines for Antiemesis to incorporate recent findings on antiemetics and cancer treatments, reflecting the latest advancements in the field
- - A thorough literature search from 1990 to 2020 was conducted to guide the update, leading to the development of 13 background questions, 12 clinical questions, and three future research questions
- - The updated guidelines aim to enhance understanding and decision-making about antiemetic therapy for both patients and healthcare providers
Article Synopsis
- The study evaluated the effectiveness of non-drug therapies for managing anticipatory chemotherapy-induced nausea and vomiting (CINV) in cancer patients, focusing on the impact of past chemotherapy experiences.
- Out of 107 studies reviewed, six were suitable for inclusion, highlighting three key non-pharmacologic treatments: systematic desensitization, hypnotherapy, and yoga therapy; systematic desensitization showed significant positive results in reducing nausea and vomiting.
- Despite promising findings for systematic desensitization, concerns about study quality and inconsistent reporting of side effects indicate a need for more rigorous research before these methods are widely adopted in clinical practice.
Article Synopsis
- - This study investigates how basal cell hyperplasia contributes to the development of eosinophilic chronic rhinosinusitis (eCRS), particularly in the nasal polyp epithelium.
- - Researchers cultured normal human bronchial epithelial cells to create two different cell types: Basal-like cells (cBC) and Epithelial cells (cEC), comparing their characteristics through various scientific methods.
- - The findings reveal that type 2 cytokines like IL-4 and IL-13 promote the growth of basal cells, which in turn produce inflammatory markers that worsen the condition in nasal polyps associated with eCRS.