Publications by authors named "Koji Kaku"
Few studies have compared the efficacy and safety of Janus kinase (JAK) inhibitors in patients with ulcerative colitis (UC). We compared the real-world effectiveness and safety of tofacitinib (TOF) and filgotinib (FIL) as induction therapy for UC by propensity score-matching analysis. We enrolled 230 patients with active UC who received either TOF (n = 197) or FIL (n = 33) as induction therapy.
View Article and Find Full Text PDFBackground: Real-world data on tofacitinib (TOF) covering a period of more than 1 year for a sufficient number of Asian patients with ulcerative colitis (UC) are scarce.
Aim: To investigate the long-term efficacy and safety of TOF treatment for UC, including clinical issues.
Methods: We performed a retrospective single-center observational analysis of 111 UC patients administered TOF at Hyogo Medical University as a tertiary inflammatory bowel disease center.
Article Synopsis
- * Researchers reviewed medical records of patients who began TED treatment between 2020 and 2021, noting significant reductions in PS volume and the percentage of patients who had a decrease of at least 20% from the start of treatment.
- * Results showed a meaningful decrease in PS volume at 8 weeks, with a median drop from about 15,825 mL to 10,700 mL per week, and no serious adverse effects were reported during the study period.
Article Synopsis
- Malignant pleural mesothelioma (MPM) is an aggressive cancer that usually affects the pleura around the lungs, often leading to serious complications like respiratory failure and weight loss.
- A unique case involved a 73-year-old man with a history of asbestos exposure, diagnosed with MPM alongside miliary pulmonary metastases and nephrotic syndrome, demonstrating unusual manifestations of the disease.
- Despite chemotherapy, the patient’s condition worsened with additional health issues, ultimately leading to his death; this case is considered the first documented instance of MPM associated with both pulmonary metastases and nephrotic syndrome.