Publications by authors named "Koichi Sudo"
Quantifying Forms and Functions of Enterohepatic Bile Acid Pools in Mice.
Cell Mol Gastroenterol Hepatol
November 2024
Backgrounds & Aims: Bile acids (BAs) are core gastrointestinal metabolites with dual functions in lipid absorption and cell signaling. BAs circulate between the liver and distal small intestine (i.e.
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- Acute immune responses can be deadly due to excess production of cytokines and other harmful substances, creating complex and unpredictable issues in the body.
- Research shows that certain triggers, like toll-like receptor (TLR) ligands and α-adrenergic receptor agonists, can lead to lethal damage in mice by increasing levels of platelet-activating factor (PAF).
- Knocking out specific genes related to immune receptors and enzymes can prevent this damage, highlighting a significant connection between the nervous and immune systems in regulating PAF levels.
Bile acids (BAs) are gastrointestinal metabolites that serve dual functions in lipid absorption and cell signaling. BAs circulate actively between the liver and distal small intestine (i.e.
View Article and Find Full Text PDFγδ T cells expressing Vγ5Vδ1 TCR originally develop in the embryonic thymus and migrate to the epidermis, forming dendritic epidermal T cells (DETCs) throughout life. It is thought that a TCR signal is essential for their development; e.g.
View Article and Find Full Text PDFAn osteoblastic protein, osteocalcin (OC), exists in vivo in two forms: carboxylated OC, and uncarboxylated or low-carboxylated OC (ucOC). ucOC acts as a hormone to regulate carbon and energy metabolism. Recent studies demonstrated that ucOC exerts insulinotropic effects, mainly through the glucagon-like peptide 1 (GLP-1) pathway.
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