Publications by authors named "Koichi Sudo"

Backgrounds & Aims: Bile acids (BAs) are core gastrointestinal metabolites with dual functions in lipid absorption and cell signaling. BAs circulate between the liver and distal small intestine (i.e.

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Article Synopsis
  • Acute immune responses can be deadly due to excess production of cytokines and other harmful substances, creating complex and unpredictable issues in the body.
  • Research shows that certain triggers, like toll-like receptor (TLR) ligands and α-adrenergic receptor agonists, can lead to lethal damage in mice by increasing levels of platelet-activating factor (PAF).
  • Knocking out specific genes related to immune receptors and enzymes can prevent this damage, highlighting a significant connection between the nervous and immune systems in regulating PAF levels.
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Bile acids (BAs) are gastrointestinal metabolites that serve dual functions in lipid absorption and cell signaling. BAs circulate actively between the liver and distal small intestine (i.e.

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γδ T cells expressing Vγ5Vδ1 TCR originally develop in the embryonic thymus and migrate to the epidermis, forming dendritic epidermal T cells (DETCs) throughout life. It is thought that a TCR signal is essential for their development; e.g.

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An osteoblastic protein, osteocalcin (OC), exists in vivo in two forms: carboxylated OC, and uncarboxylated or low-carboxylated OC (ucOC). ucOC acts as a hormone to regulate carbon and energy metabolism. Recent studies demonstrated that ucOC exerts insulinotropic effects, mainly through the glucagon-like peptide 1 (GLP-1) pathway.

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