R&D of JAEA for the decommissioning of TEPCO's Fukushima Daiichi nuclear power station.

This paper does not necessarily reflect the views of the International Commission on Radiological Protection.Since the accident at Fukushima Daiichi nuclear power station in March 2011, Japan Atomic Energy Agency (JAEA) has been contributing actively to the environmental recovery of Fukushima and the decommissioning of Fukushima Daiichi nuclear power station from a technical aspect, through a wide range of research and development (R&D) activities including fundamental research and applicational technology development. JAEA has been conducting R&D such as the characterisation of fuel debris, and treatment and disposal of radioactive wastes based on the 'Mid-and-Long-Term Roadmap' authorised by the Japanese Government.

Multicenter Study of Intravenous Recombinant Tissue Plasminogen Activator Infusion around Hiroshima, Japan: The Hiroshima Acute Stroke Retrospective and Prospective Registry Study.

Objective: Approximately 10 years have passed since intravenous (IV) recombinant tissue plasminogen activator therapy was approved in Japan. The aim of this retrospective study was to identify the effectiveness and safety of IV alteplase therapy with the Japanese original dose around Hiroshima via consideration of the patients' backgrounds, examination findings, and outcomes.

Methods: All consecutive patients with ischemic stroke who received IV alteplase therapy between October 2005 and October 2010 were registered.

Subsequent vascular events after ischemic stroke: the Japan Statin Treatment Against Recurrent Stroke-Longitudinal.

Background: We undertook a multicenter cohort observational study to investigate the frequency and type of subsequent vascular events after an ischemic stroke and to compare the rates of vascular events between patients with and without hyperlipidemia.

Methods: This nationwide study was conducted in 19 hospitals participating in the Japan Standard Stroke Registry Study. We enrolled ischemic stroke patients, including those with a transient ischemic attack, who had not experienced any vascular events before enrollment after their ischemic stroke events.

Relationship between neuronal loss and tangle formation in neurons and oligodendroglia in progressive supranuclear palsy.

Progressive supranuclear palsy (PSP) is a progressive degenerative disorder characterized by neuronal loss, gliosis and abnormal fibril formation of abnormally phosphorylated tau protein in neurons and glia cells, but the cause is not clear at present. For the purpose of clarifying the pathological significance of accumulation of tau protein in neurons and oligodendroglia in PSP, we morphologically classified neurofibrillary tangles (NFT) and coiled bodies (CB) in oligodendroglia in three PSP brains into four stages, using double staining for immunohistochemistry with AT8 antibody and modified Gallyas-Braak (GB) staining. AT8-positive neurons without abnormal fibril structure with GB staining were classified as stage I, AT8-positive neurons containing a few fibril structures with GB staining were classified stage II, AT8-positive neurons containing mature fibril structures were classified as stage III, and AT8 negative neurons containing abnormal fibril structures stained only with GB staining were classified as stage IV (ghost tangles).

An unexpected outbreak of Japanese encephalitis in the Chugoku district of Japan, 2002.

Six patients unexpectedly presented with Japanese encephalitis (JE) from early August to mid-September 2002 in the Chugoku district of Japan. The mean age was 67.5 years (range 42 - 89 years); the onset period in two patients shifted to the middle of September.

Light and Electron Microscopic Studies on Fertilization of Pelmatohydra Robusta I. Sperm Entry to a Specialized Region of the Egg.

Fertilization of a fresh water polyp, Pelmatohydra robusta, was studied by light and electron microscopy. A small depression was observed in the animal pole of the unfertilized egg. The egg pronucleus was always situated in close contact with the bottom of the depression.