Preparation and facile addition reactions of iminium salts derived from amino ketene silyl acetal and amino silyl enol ether.

While iminium salts generated by the oxidation of amino ketene silyl acetals show intriguing reactivities to give useful γ-oxo-α-amino esters reactions with silyl enol ethers in good yields, new iminium salts are also prepared by the oxidation of amino silyl enol ethers. They undergo facile addition reaction with various nucleophiles to give α-amino ketone derivatives in good yields.

Impact of Carbohydrate-Electrolyte Beverage Ingestion on Heart Rate Response While Climbing Mountain Fuji at ~3000 m.

We sought to investigate whether carbohydrate-electrolyte beverage ingestion reduced heart rate (HR) in twenty-three healthy young adults while climbing Mount Fuji at a given exercise intensity. Twenty-three healthy adults were randomly divided into two groups: the tap water (11 males [M] and 1 female [F]) and the carbohydrate-electrolyte group (10 M and 1 F). HR and activity energy expenditure (AEE) were recorded every min.

Flexible heat-flow sensing sheets based on the longitudinal spin Seebeck effect using one-dimensional spin-current conducting films.

Heat-flow sensing is expected to be an important technological component of smart thermal management in the future. Conventionally, the thermoelectric (TE) conversion technique, which is based on the Seebeck effect, has been used to measure a heat flow by converting the flow into electric voltage. However, for ubiquitous heat-flow visualization, thin and flexible sensors with extremely low thermal resistance are highly desired.

[Rapid progressive focal myositis of the head and neck region: a case report].

A 46-year-old woman noticed a painful lump in the neck following fluctuating multiple arthralgia in the previous 3 months. The neck nodule grew rapidly, and was associated with an elevation of the serum creatine kinase activity. Under a diagnosis of focal myositis, corticosteroids were introduced, soon resulting in an amelioration of the symptoms.

Effects of tacrolimus on dermatomyositis and polymyositis: a prospective, open, non-randomized study of nine patients and a review of the literature.

Dermatomyositis (DM) and polymyositis (PM) are often refractory to conventional therapy with corticosteroids sometimes combined with immune-suppressing agents and can lead to severe disability if these treatments are unsuccessful. In this prospective, open, non-randomized study, we examined the efficacy of tacrolimus (FK506), an immunosuppressant, in nine patients with DM (n = 5) or PM (n = 4) who did not respond to previous therapy. Outcomes included compound muscle strength, ambulatory status, and serum creatine kinase activity measured at intervals after starting tacrolimus.

In situ observations of domain structures and magnetic flux distributions in Mn-Zn and Ni-Zn ferrites by Lorentz microscopy and electron holography.

Domain structures and magnetic flux distributions in Mn-Zn and Ni-Zn ferrites are investigated by in situ observations with Lorentz microscopy and electron holography. In situ Lorentz microscopic observation with the magnetic field applied reveals that the domain walls in Mn-Zn ferrite move easily across the grain boundary. On the other hand, each grain of Ni-Zn ferrite is magnetized by domain wall motion inside the grain.

A new insertion sequence IS1452 from Acetobacter pasteurianus.

A new insertion sequence element, IS1452, was found to be associated with inactivation of the alcohol dehydrogenase by insertion in the adhS gene encoding subunit III of the three-component membrane-bound alcohol dehydrogenase complex in Acetobacter pasteurianus. Cloning and sequencing analyses of the mutated subunit III gene locus revealed that IS1452 was inserted at or near the ribosome-binding sequence of adhS. Analysis of transcription using the chloramphenicol acetyltransferase gene as the reporter indicated that IS1452 abolished transcription of adhS by separating its promoter from the subunit III structural gene.