Publications by authors named "Kohei Ohyama"
Article Synopsis
- Observational studies utilizing real-world data (real-world evidence) are increasingly being integrated into drug development and policymaking, highlighting the importance of a solid quality management system for accurate data collection.
- Our study on a specific intractable disease employed a comprehensive risk-based quality management approach to assess and mitigate potential risks associated with this real-world data analysis.
- We concluded that using a risk-based framework is not only feasible but essential in ensuring the validity of outcomes and the quality of databases in observational studies, ultimately leading to more reliable real-world evidence.
Background: Cancer incidence is expected to increase with population aging, making the availability of places for treating patients with terminal cancer a pressing issue. However, little is known about the actual state of home end-of-life care (HEC) in Japan.
Objective: The objective of this study was to examine the real-world state of HEC for older adults with cancer.
Push-pull type fluorescent amino-quinoline derivatives (TFMAQ) bearing phenyl aromatic groups in the 8-position (TFMAQ-8Ar series) were synthesized via palladium-catalyzed C-H activation reaction in short steps. The N-arylation or C-H activation reactions were selectively controlled with high yield by combinations of palladium and phosphine ligands. The TFMAQ-8Ar analogues exhibited fluorescent solvatochromism in non-polar and polar solvents.
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