Publications by authors named "Kohei Kawai"

Article Synopsis
  • Hypertension is a known risk factor for atrial fibrillation (AF) and strokes, but there is limited research on AF screening in hypertensive patients and its link to blood pressure levels.
  • A study involving over 4,000 hypertensive patients aged 60 and older in Japan measured their electrocardiograms (ECG) and blood pressure (BP) at home for three months.
  • The study found that 5.8% of participants had undiagnosed AF, with no significant differences in AF detection rates based on different baseline BP categories or the use of antihypertensive medication.
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Article Synopsis
  • Atrial fibrillation (AF) is categorized by duration into paroxysmal, persistent, and long-standing persistent types, with longer durations increasing the risk of recurrence during catheter ablation treatment.
  • The study aims to enhance the diagnosis accuracy of AF duration through a predictive model, utilizing data from 272 patients to train a machine learning algorithm.
  • Results showed the model achieved 81.8% accuracy in predicting AF duration, significantly improving cardiologists' diagnostic performance from 63.9% to 71.6% after using the model's insights.
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Site-selective nucleophilic ring-opening reactions of 2-arylazetidine-2-carboxylic acid ester-derived tetraalkyl ammonium salts 2 with tetrabutylammonium halides (BuNX) to give tertiary alkyl halides are successfully demonstrated. For example, a nucleophilic ring-opening reaction of 2-(-tolyl) derivative 2a with 1.2 equivalents of tetrabutylammonium fluoride (BuNF) in THF at 60 °C preferentially proceeded at a more substituted carbon atom (2-position) compared to a less-substituted carbon atom (4-position) and afforded -butyl 4-(dimethylamino)-2-fluoro-2-(-tolyl)butanoate 3aa in 71% yield as the corresponding tertiary alkyl fluoride.

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In order to fully understand the role of volatile organic compounds (VOCs) under natural conditions, an adaptable analytical method was developed as the first step. beta-Ionone, beta-cyclocitral, 2-methyl-1-butanol and 3-methyl-1-butanol were simultaneously analyzed in addition to geosmin and 2-MIB using GC/MS with SPME. The slight modification of a known method allowed the simultaneous detection and quantification of these VOCs.

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