Publications by authors named "Koh-Hei Yamada"
Antivir Chem Chemother
June 2019
Article Synopsis
- A compound named 35C10 was identified as a potential inhibitor of human cytomegalovirus (HCMV) during screenings of anti-HCMV compounds using a specialized reporter cell line.
- Testing revealed that 35C10 had an effective concentration (EC50) of 4.3 µM and demonstrated low cytotoxicity (CC50 > 200 µM), with some derivatives showing similar properties.
- The compound appears to hinder early phases of HCMV infection by reducing immediate-early protein expression, indicating its potential as a new treatment to combat HCMV-related infections.
