Publications by authors named "Koh Jiayun"

Background: The rapid spread of the coronavirus disease 2019 (COVID-19) pandemic demonstrates the value of regional cooperation in infectious disease prevention and control. We explored the literature on regional infectious disease control bodies, to identify lessons, barriers and enablers to inform operationalisation of a regional infectious disease control body or network in southeast Asia.

Methods: We conducted a scoping review to examine existing literature on regional infectious disease control bodies and networks, and to identify lessons that can be learned that will be useful for operationalisation of a regional infectious disease control body such as the Association of Southeast Asian Nations (ASEAN) Center for Public Health Emergency and Emerging Diseases.

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This study assessed the impact of weather factors, including novel predictors-pollutant standards index (PSI) and wind speed-on dengue incidence in Singapore between 2012 and 2019. Autoregressive integrated moving average (ARIMA) model was fitted to explore the autocorrelation in time series and quasi-Poisson model with a distributed lag non-linear term (DLNM) was set up to assess any non-linear association between climatic factors and dengue incidence. In DLNM, a PSI level of up to 111 was positively associated with dengue incidence; incidence reduced as PSI level increased to 160.

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Successful detection of SARS-COV-2 in wastewater suggests the potential utility of wastewater-based epidemiology (WBE) for COVID-19 community surveillance. This systematic review aims to assess the performance of wastewater surveillance as early warning system of COVID-19 community transmission. A systematic search was conducted in PubMed, Medline, Embase and the WBE Consortium Registry according to PRISMA guidelines for relevant articles published until 31st July 2021.

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Article Synopsis
  • * Patients from Wuhan showed higher mean age and rates of severe symptoms such as dyspnea, myalgia, and ARDS compared to patients from other regions, indicating more severe disease in that area.
  • * The findings revealed that pediatric patients had a higher proportion of asymptomatic cases, while disease severity increased with age; suggesting that biomarkers at admission could help in predicting patient prognosis.
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Article Synopsis
  • A cluster of pneumonia cases was first identified in Wuhan, China, on December 29, 2019, prompting a systematic review of early COVID-19 cases' epidemiological and clinical characteristics.
  • The review analyzed 29 peer-reviewed studies published between January and February 2020, focusing on 533 adult patients with a median age of 56, and highlighted the common symptoms experienced, including fever, cough, and fatigue.
  • Key findings indicated that ICU patients were more likely to present with shortness of breath and had higher rates of pre-existing conditions like hypertension and cardiovascular disease.
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Background: Acute respiratory infections (ARI), including the common cold causes significant morbidity and economical losses globally. Micronutrient deficiency may increase ARI incidence risk and its associated duration and severity among healthy adults, but evidence are inconclusive. This study aims to systematically review all observations on the association between single micronutrient deficiency and ARI incidence, duration and severity in healthy adults.

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